Neonatal hemochromatosis: Fetal liver disease leading to liver failure in the fetus and newborn

Peter F Whitington*, Susan Kelly, Udeme D. Ekong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Acute liver failure in the newborn is relatively rare but often fatal. The broadest definition of acute liver failure is failure of the vital functions of the liver occurring within weeks or a few months of the onset of clinical liver disease. Therefore, by definition, any liver failure in the newborn can be construed to be acute liver failure. A second component of the general definition of acute liver failure is the lack of known preexisting liver disease. In the case of neonatal acute liver failure, preexisting disease would by definition be liver disease that affects the fetus. Almost nothing is known about fetal onset liver failure, and there is no literature addressing the subject. This review will address fetal liver disease that leads to liver failure in the fetus or newborn.

Original languageEnglish (US)
Pages (from-to)640-645
Number of pages6
JournalPediatric Transplantation
Volume9
Issue number5
DOIs
StatePublished - Oct 1 2005

Keywords

  • Acute liver failure
  • Alloimmune
  • Fetus
  • Neonatal hemochromatosis
  • Newborn

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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