TY - JOUR
T1 - Neonatal host defense against staphylococcal infections
AU - Power Coombs, Melanie R.
AU - Kronforst, Kenny
AU - Levy, Ofer
PY - 2013
Y1 - 2013
N2 - Preterm infants are especially susceptible to late-onset sepsis that is often due to Gram-positive bacterial infections resulting in substantial morbidity and mortality. Herein, we will describe neonatal innate immunity to Staphylococcus spp. comparing differences between preterm and full-term newborns with adults. Newborn innate immunity is distinct demonstrating diminished skin integrity, impaired Th1-polarizing responses, low complement levels, and diminished expression of plasma antimicrobial proteins and peptides, especially in preterm newborns. Characterization of distinct aspects of the neonatal immune response is defining novel approaches to enhance host defense to prevent and/or treat staphylococcal infection in this vulnerable population.
AB - Preterm infants are especially susceptible to late-onset sepsis that is often due to Gram-positive bacterial infections resulting in substantial morbidity and mortality. Herein, we will describe neonatal innate immunity to Staphylococcus spp. comparing differences between preterm and full-term newborns with adults. Newborn innate immunity is distinct demonstrating diminished skin integrity, impaired Th1-polarizing responses, low complement levels, and diminished expression of plasma antimicrobial proteins and peptides, especially in preterm newborns. Characterization of distinct aspects of the neonatal immune response is defining novel approaches to enhance host defense to prevent and/or treat staphylococcal infection in this vulnerable population.
UR - http://www.scopus.com/inward/record.url?scp=84880909338&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880909338&partnerID=8YFLogxK
U2 - 10.1155/2013/826303
DO - 10.1155/2013/826303
M3 - Review article
C2 - 23935651
AN - SCOPUS:84880909338
VL - 2013
JO - Clinical and Developmental Immunology
JF - Clinical and Developmental Immunology
SN - 2314-8861
M1 - 826303
ER -