Neonatal host defense against staphylococcal infections

Melanie R. Power Coombs, Kenny Kronforst, Ofer Levy*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Preterm infants are especially susceptible to late-onset sepsis that is often due to Gram-positive bacterial infections resulting in substantial morbidity and mortality. Herein, we will describe neonatal innate immunity to Staphylococcus spp. comparing differences between preterm and full-term newborns with adults. Newborn innate immunity is distinct demonstrating diminished skin integrity, impaired Th1-polarizing responses, low complement levels, and diminished expression of plasma antimicrobial proteins and peptides, especially in preterm newborns. Characterization of distinct aspects of the neonatal immune response is defining novel approaches to enhance host defense to prevent and/or treat staphylococcal infection in this vulnerable population.

Original languageEnglish (US)
Article number826303
JournalClinical and Developmental Immunology
Volume2013
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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