Neonatal Hypoxia Results in Peripheral Nerve Abnormalities

Benjamin L.L. Clayton, Aaron Huang, Danuta Dukala, Betty Soliven, Brian Popko*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Although the adverse effects of neonatal hypoxia associated with premature birth on the central nervous system are well known, the contribution of hypoxic damage to the peripheral nervous system (PNS) has not been addressed. We demonstrate that neonatal hypoxia results in hypomyelination and delayed axonal sorting in mice leading to electrophysiological and motor deficits that persist into adulthood. These findings support a potential role for PNS hypoxic damage in the motor impairment that results from premature birth and suggest that therapies designed to protect the PNS may provide clinical benefit.

Original languageEnglish (US)
Pages (from-to)245-251
Number of pages7
JournalAmerican Journal of Pathology
Volume187
Issue number2
DOIs
StatePublished - Feb 1 2017

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Neonatal Hypoxia Results in Peripheral Nerve Abnormalities'. Together they form a unique fingerprint.

Cite this