Abstract
Immunity in the newborn is characterized by minimal T helper (Th)1 function but an excess of Th2 activity. Since Th1 lymphocytes are important to counter microbes and Th2 cells favor allergies, the newborn faces susceptibility to microbial infections and allergic reactions. Delayed maturation of certain dendritic cells leads to limited interleukin (IL)-12 production during the neonatal period. The Th2 cytokine locus of neonatal CD4 + T cells is poised epigenetically for rapid and robust production of IL-4 and IL-13. Together, these circumstances lead to efficient differentiation of Th2 cells and the expression of an IL-4Rα/IL-13Rα1 heteroreceptor on Th1 cells. Upon re-challenge, Th2 cells rapidly produce IL-4 which utilizes the heteroreceptor to drive apoptosis of Th1 cells, thus yielding the Th2 bias of neonatal immunity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 585-591 |
| Number of pages | 7 |
| Journal | Trends in Immunology |
| Volume | 30 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2009 |
Fingerprint
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
}
Neonatal immunity : faulty T-helpers and the shortcomings of dendritic cells. / Zaghouani, Habib; Hoeman, Christine M.; Adkins, Becky.
In: Trends in Immunology, Vol. 30, No. 12, 01.12.2009, p. 585-591.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Neonatal immunity
T2 - faulty T-helpers and the shortcomings of dendritic cells
AU - Zaghouani, Habib
AU - Hoeman, Christine M.
AU - Adkins, Becky
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Immunity in the newborn is characterized by minimal T helper (Th)1 function but an excess of Th2 activity. Since Th1 lymphocytes are important to counter microbes and Th2 cells favor allergies, the newborn faces susceptibility to microbial infections and allergic reactions. Delayed maturation of certain dendritic cells leads to limited interleukin (IL)-12 production during the neonatal period. The Th2 cytokine locus of neonatal CD4 + T cells is poised epigenetically for rapid and robust production of IL-4 and IL-13. Together, these circumstances lead to efficient differentiation of Th2 cells and the expression of an IL-4Rα/IL-13Rα1 heteroreceptor on Th1 cells. Upon re-challenge, Th2 cells rapidly produce IL-4 which utilizes the heteroreceptor to drive apoptosis of Th1 cells, thus yielding the Th2 bias of neonatal immunity.
AB - Immunity in the newborn is characterized by minimal T helper (Th)1 function but an excess of Th2 activity. Since Th1 lymphocytes are important to counter microbes and Th2 cells favor allergies, the newborn faces susceptibility to microbial infections and allergic reactions. Delayed maturation of certain dendritic cells leads to limited interleukin (IL)-12 production during the neonatal period. The Th2 cytokine locus of neonatal CD4 + T cells is poised epigenetically for rapid and robust production of IL-4 and IL-13. Together, these circumstances lead to efficient differentiation of Th2 cells and the expression of an IL-4Rα/IL-13Rα1 heteroreceptor on Th1 cells. Upon re-challenge, Th2 cells rapidly produce IL-4 which utilizes the heteroreceptor to drive apoptosis of Th1 cells, thus yielding the Th2 bias of neonatal immunity.
UR - http://www.scopus.com/inward/record.url?scp=70449629815&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70449629815&partnerID=8YFLogxK
U2 - 10.1016/j.it.2009.09.002
DO - 10.1016/j.it.2009.09.002
M3 - Review article
VL - 30
SP - 585
EP - 591
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 12
ER -