Neonatal outcomes in twin pregnancies delivered moderately preterm, late preterm, and term

Jerrie S. Refuerzo; Valerija Momirova; Alan M. Peaceman; Anthony Sciscione; Dwight J. Rouse; Steve N. Caritis; Catherine Y. Spong; Michael W. Varner; Fergal D. Malone; Jay D. Iams; Brian M. Mercer; John M. Thorp; Yoram Sorokin; Marshall W. Carpenter; Julie Lo; Margaret Harper

doi:10.1055/s-0030-1248940

Neonatal outcomes in twin pregnancies delivered moderately preterm, late preterm, and term

Jerrie S. Refuerzo, Valerija Momirova, Alan M. Peaceman, Anthony Sciscione, Dwight J. Rouse, Steve N. Caritis, Catherine Y. Spong, Michael W. Varner, Fergal D. Malone, Jay D. Iams, Brian M. Mercer, John M. Thorp, Yoram Sorokin, Marshall W. Carpenter, Julie Lo, Margaret Harper

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

We compared neonatal outcomes in twin pregnancies following moderately preterm birth (MPTB), late preterm birth (LPTB), and term birth. A secondary analysis of a multicenter, randomized controlled trial of multiple gestations was conducted. MPTB was defined as delivery between 32^0/7 and 33 ^6/7 weeks and LPTB between 34^0/7 and 36^6/7 weeks. Primary outcome was a neonatal outcome composite consisting of one or more of the following: Neonatal death, respiratory distress syndrome, early onset culture-proven sepsis, stage 2 or 3 necrotizing enterocolitis, bronchopulmonary dysplasia, grade 3 or 4 intraventricular hemorrhage, periventricular leukomalacia, pneumonia, or severe retinopathy of prematurity. Among 552 twin pregnancies, the MPTB rate was 14.5%, LPTB 49.8%, and term birth rate 35.7%. The rate of the primary outcome was different between groups: 30.0% for MPTB, 12.8% for LPTB, 0.5% for term birth (p<0.001). Compared with term neonates, the primary neonatal outcome composite was increased following MPTB (relative risk [RR] 58.5; 95% confidence interval [CI] 11.3 to 1693.0) and LPTB (RR 24.9; 95% CI 4.8 to 732.2). Twin pregnancies born moderately and late preterm encounter higher rates of neonatal morbidities compared with twins born at term.

Original language	English (US)
Pages (from-to)	537-542
Number of pages	6
Journal	American journal of perinatology
Volume	27
Issue number	7
DOIs	https://doi.org/10.1055/s-0030-1248940
State	Published - 2010

Keywords

Twin pregnancy
late preterm birth
neonatal morbidities

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1055/s-0030-1248940

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Refuerzo, J. S., Momirova, V., Peaceman, A. M., Sciscione, A., Rouse, D. J., Caritis, S. N., Spong, C. Y., Varner, M. W., Malone, F. D., Iams, J. D., Mercer, B. M., Thorp, J. M., Sorokin, Y., Carpenter, M. W., Lo, J., & Harper, M. (2010). Neonatal outcomes in twin pregnancies delivered moderately preterm, late preterm, and term. American journal of perinatology, 27(7), 537-542. https://doi.org/10.1055/s-0030-1248940

Refuerzo, Jerrie S. ; Momirova, Valerija ; Peaceman, Alan M. ; Sciscione, Anthony ; Rouse, Dwight J. ; Caritis, Steve N. ; Spong, Catherine Y. ; Varner, Michael W. ; Malone, Fergal D. ; Iams, Jay D. ; Mercer, Brian M. ; Thorp, John M. ; Sorokin, Yoram ; Carpenter, Marshall W. ; Lo, Julie ; Harper, Margaret. / Neonatal outcomes in twin pregnancies delivered moderately preterm, late preterm, and term. In: American journal of perinatology. 2010 ; Vol. 27, No. 7. pp. 537-542.

@article{d175406313c34b1dab83504c5c5777ec,

title = "Neonatal outcomes in twin pregnancies delivered moderately preterm, late preterm, and term",

abstract = "We compared neonatal outcomes in twin pregnancies following moderately preterm birth (MPTB), late preterm birth (LPTB), and term birth. A secondary analysis of a multicenter, randomized controlled trial of multiple gestations was conducted. MPTB was defined as delivery between 320/7 and 33 6/7 weeks and LPTB between 340/7 and 366/7 weeks. Primary outcome was a neonatal outcome composite consisting of one or more of the following: Neonatal death, respiratory distress syndrome, early onset culture-proven sepsis, stage 2 or 3 necrotizing enterocolitis, bronchopulmonary dysplasia, grade 3 or 4 intraventricular hemorrhage, periventricular leukomalacia, pneumonia, or severe retinopathy of prematurity. Among 552 twin pregnancies, the MPTB rate was 14.5%, LPTB 49.8%, and term birth rate 35.7%. The rate of the primary outcome was different between groups: 30.0% for MPTB, 12.8% for LPTB, 0.5% for term birth (p<0.001). Compared with term neonates, the primary neonatal outcome composite was increased following MPTB (relative risk [RR] 58.5; 95% confidence interval [CI] 11.3 to 1693.0) and LPTB (RR 24.9; 95% CI 4.8 to 732.2). Twin pregnancies born moderately and late preterm encounter higher rates of neonatal morbidities compared with twins born at term.",

keywords = "Twin pregnancy, late preterm birth, neonatal morbidities",

author = "Refuerzo, {Jerrie S.} and Valerija Momirova and Peaceman, {Alan M.} and Anthony Sciscione and Rouse, {Dwight J.} and Caritis, {Steve N.} and Spong, {Catherine Y.} and Varner, {Michael W.} and Malone, {Fergal D.} and Iams, {Jay D.} and Mercer, {Brian M.} and Thorp, {John M.} and Yoram Sorokin and Carpenter, {Marshall W.} and Julie Lo and Margaret Harper",

year = "2010",

doi = "10.1055/s-0030-1248940",

language = "English (US)",

volume = "27",

pages = "537--542",

journal = "American Journal of Perinatology",

issn = "0735-1631",

publisher = "Thieme Medical Publishers",

number = "7",

}

Refuerzo, JS, Momirova, V, Peaceman, AM, Sciscione, A, Rouse, DJ, Caritis, SN, Spong, CY, Varner, MW, Malone, FD, Iams, JD, Mercer, BM, Thorp, JM, Sorokin, Y, Carpenter, MW, Lo, J & Harper, M 2010, 'Neonatal outcomes in twin pregnancies delivered moderately preterm, late preterm, and term', American journal of perinatology, vol. 27, no. 7, pp. 537-542. https://doi.org/10.1055/s-0030-1248940

Neonatal outcomes in twin pregnancies delivered moderately preterm, late preterm, and term. / Refuerzo, Jerrie S.; Momirova, Valerija; Peaceman, Alan M.; Sciscione, Anthony; Rouse, Dwight J.; Caritis, Steve N.; Spong, Catherine Y.; Varner, Michael W.; Malone, Fergal D.; Iams, Jay D.; Mercer, Brian M.; Thorp, John M.; Sorokin, Yoram; Carpenter, Marshall W.; Lo, Julie; Harper, Margaret.

In: American journal of perinatology, Vol. 27, No. 7, 2010, p. 537-542.

Research output: Contribution to journal › Article › peer-review

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T1 - Neonatal outcomes in twin pregnancies delivered moderately preterm, late preterm, and term

AU - Refuerzo, Jerrie S.

AU - Momirova, Valerija

AU - Peaceman, Alan M.

AU - Sciscione, Anthony

AU - Rouse, Dwight J.

AU - Caritis, Steve N.

AU - Spong, Catherine Y.

AU - Varner, Michael W.

AU - Malone, Fergal D.

AU - Iams, Jay D.

AU - Mercer, Brian M.

AU - Thorp, John M.

AU - Sorokin, Yoram

AU - Carpenter, Marshall W.

AU - Lo, Julie

AU - Harper, Margaret

PY - 2010

Y1 - 2010

N2 - We compared neonatal outcomes in twin pregnancies following moderately preterm birth (MPTB), late preterm birth (LPTB), and term birth. A secondary analysis of a multicenter, randomized controlled trial of multiple gestations was conducted. MPTB was defined as delivery between 320/7 and 33 6/7 weeks and LPTB between 340/7 and 366/7 weeks. Primary outcome was a neonatal outcome composite consisting of one or more of the following: Neonatal death, respiratory distress syndrome, early onset culture-proven sepsis, stage 2 or 3 necrotizing enterocolitis, bronchopulmonary dysplasia, grade 3 or 4 intraventricular hemorrhage, periventricular leukomalacia, pneumonia, or severe retinopathy of prematurity. Among 552 twin pregnancies, the MPTB rate was 14.5%, LPTB 49.8%, and term birth rate 35.7%. The rate of the primary outcome was different between groups: 30.0% for MPTB, 12.8% for LPTB, 0.5% for term birth (p<0.001). Compared with term neonates, the primary neonatal outcome composite was increased following MPTB (relative risk [RR] 58.5; 95% confidence interval [CI] 11.3 to 1693.0) and LPTB (RR 24.9; 95% CI 4.8 to 732.2). Twin pregnancies born moderately and late preterm encounter higher rates of neonatal morbidities compared with twins born at term.

AB - We compared neonatal outcomes in twin pregnancies following moderately preterm birth (MPTB), late preterm birth (LPTB), and term birth. A secondary analysis of a multicenter, randomized controlled trial of multiple gestations was conducted. MPTB was defined as delivery between 320/7 and 33 6/7 weeks and LPTB between 340/7 and 366/7 weeks. Primary outcome was a neonatal outcome composite consisting of one or more of the following: Neonatal death, respiratory distress syndrome, early onset culture-proven sepsis, stage 2 or 3 necrotizing enterocolitis, bronchopulmonary dysplasia, grade 3 or 4 intraventricular hemorrhage, periventricular leukomalacia, pneumonia, or severe retinopathy of prematurity. Among 552 twin pregnancies, the MPTB rate was 14.5%, LPTB 49.8%, and term birth rate 35.7%. The rate of the primary outcome was different between groups: 30.0% for MPTB, 12.8% for LPTB, 0.5% for term birth (p<0.001). Compared with term neonates, the primary neonatal outcome composite was increased following MPTB (relative risk [RR] 58.5; 95% confidence interval [CI] 11.3 to 1693.0) and LPTB (RR 24.9; 95% CI 4.8 to 732.2). Twin pregnancies born moderately and late preterm encounter higher rates of neonatal morbidities compared with twins born at term.

KW - Twin pregnancy

KW - late preterm birth

KW - neonatal morbidities

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JO - American Journal of Perinatology

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ER -

Neonatal outcomes in twin pregnancies delivered moderately preterm, late preterm, and term

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