Nephrotoxicity of xenobiotics

Mario Werner*, Michael J. Costa, Lloyd G. Mitchell, Ritu Nayar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Nephrotoxicity can be grouped by the xenobiotics place of action, by the clinical presentation or by the generic toxic effect. The latter can be dose related, indirect, idiosyncratic or allergic. Nephrotoxicity of lithium, demeclocycline, aminoglycosides, cyclosporine, mercuric ion, nonsteroidal anti-inflammatory drugs, methoxyflurane, ethylene glycol, D-penicillamine and methicillin is reviewed in light of all these three viewpoints, but emphasis is on toxic mechanisms.

Original languageEnglish (US)
Pages (from-to)107-154
Number of pages48
JournalClinica Chimica Acta
Issue number1-2
StatePublished - Jun 15 1995


  • Aminoglycosides
  • Cyclosporine
  • Demeclocycline
  • Ethylene glycol
  • Lithium
  • Mercury
  • Methicillin
  • Methoxyflurane
  • Nonsteroidal anti-inflammatory drugs
  • d-penicillamine

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical


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