Abstract
Approximately one-third of hypertensive patients with thyroid dysfunction become normotensive on restoration to the euthyroid state. Considerable evidence suggests that the nervous system is involved in these responses, but the mechanism has been obscure. New information demonstrates that iodothyronines are localized and processed in discrete neural systems in rat brain. Moreover, following a latent period, heart rate is significantly increased by intrathecal administration of triiodothyronine in a dose which sustains but does not increase heart rate when given intravenously. These observations add to existing biochemical and autoradiographic evidence that autonomic effects of iodocompounds may be mediated through direct neuroregulatory (neuromodulator and neurotransmitter) functions within the nervous system.
Original language | English (US) |
---|---|
Pages (from-to) | 611-619 |
Number of pages | 9 |
Journal | Life Sciences |
Volume | 30 |
Issue number | 7-8 |
DOIs | |
State | Published - Feb 1982 |
Funding
We thank Dr. Anthony S. Jennings for serum T3 assays and Ms. Effie K. Erlichman for editorial and technical assistance. This work was supported by funds from the Medical Research Service, Veterans Administration Medical Center, Philadelphia, Pa. and NIMH Grant #MH29549. Dr. Morris Goldman's present address is University of Chicago, Chicago, Illinois 60637.
ASJC Scopus subject areas
- General Pharmacology, Toxicology and Pharmaceutics
- General Biochemistry, Genetics and Molecular Biology