NetPath: A public resource of curated signal transduction pathways

Kumaran Kandasamy; S. Sujatha Mohan; Rajesh Raju; Shivakumar Keerthikumar; Ghantasala S. Sameer Kumar; Abhilash K. Venugopal; Deepthi Telikicherla; Daniel J. Navarro; Suresh Mathivanan; Christian Pecquet; Sashi Kanth Gollapudi; Sudhir Gopal Tattikota; Shyam Mohan; Hariprasad Padhukasahasram; Yashwanth Subbannayya; Renu Goel; Harrys K.C. Jacob; Jun Zhong; Raja Sekhar; Vishalakshi Nanjappa; Lavanya Balakrishnan; Roopashree Subbaiah; Y. L. Ramachandra; B. Abdul Rahiman; T. S. Keshava Prasad; Jian Xin Lin; Jon C.D. Houtman; Stephen Desiderio; Jean Christophe Renauld; Stefan Constantinescu; Osamu Ohara; Toshio Hirano; Masato Kubo; Sujay Singh; Purvesh Khatri; Sorin Draghici; Gary D. Bader; Chris Sander; Warren J. Leonard; Akhilesh Pandey

doi:10.1186/gb-2010-11-1-r3

NetPath: A public resource of curated signal transduction pathways

Kumaran Kandasamy, S. Sujatha Mohan, Rajesh Raju, Shivakumar Keerthikumar, Ghantasala S. Sameer Kumar, Abhilash K. Venugopal, Deepthi Telikicherla, Daniel J. Navarro, Suresh Mathivanan, Christian Pecquet, Sashi Kanth Gollapudi, Sudhir Gopal Tattikota, Shyam Mohan, Hariprasad Padhukasahasram, Yashwanth Subbannayya, Renu Goel, Harrys K.C. Jacob, Jun Zhong, Raja Sekhar, Vishalakshi NanjappaLavanya Balakrishnan, Roopashree Subbaiah, Y. L. Ramachandra, B. Abdul Rahiman, T. S. Keshava Prasad, Jian Xin Lin, Jon C.D. Houtman, Stephen Desiderio, Jean Christophe Renauld, Stefan Constantinescu, Osamu Ohara, Toshio Hirano, Masato Kubo, Sujay Singh, Purvesh Khatri, Sorin Draghici, Gary D. Bader, Chris Sander, Warren J. Leonard, Akhilesh Pandey^*

^*Corresponding author for this work

PCE - Proteomics Center of Excellence

Research output: Contribution to journal › Article › peer-review

335 Scopus citations

Abstract

We have developed NetPath as a resource of curated human signaling pathways. As an initial step, NetPath provides detailed maps of a number of immune signaling pathways, which include ~1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally-regulated genes - all linked to over 5,500 published articles. We anticipate NetPath to become a consolidated resource for human signaling pathways that should enable systems biology approaches.

Original language	English (US)
Article number	r3
Journal	Genome biology
Volume	11
Issue number	1
DOIs	https://doi.org/10.1186/gb-2010-11-1-r3
State	Published - Jan 12 2010

ASJC Scopus subject areas

Genetics
Ecology, Evolution, Behavior and Systematics
Cell Biology

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10.1186/gb-2010-11-1-r3

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Kandasamy, K., Sujatha Mohan, S., Raju, R., Keerthikumar, S., Sameer Kumar, G. S., Venugopal, A. K., Telikicherla, D., Navarro, D. J., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., ... Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. Genome biology, 11(1), [r3]. https://doi.org/10.1186/gb-2010-11-1-r3

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title = "NetPath: A public resource of curated signal transduction pathways",

abstract = "We have developed NetPath as a resource of curated human signaling pathways. As an initial step, NetPath provides detailed maps of a number of immune signaling pathways, which include ~1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally-regulated genes - all linked to over 5,500 published articles. We anticipate NetPath to become a consolidated resource for human signaling pathways that should enable systems biology approaches.",

author = "Kumaran Kandasamy and {Sujatha Mohan}, S. and Rajesh Raju and Shivakumar Keerthikumar and {Sameer Kumar}, {Ghantasala S.} and Venugopal, {Abhilash K.} and Deepthi Telikicherla and Navarro, {Daniel J.} and Suresh Mathivanan and Christian Pecquet and Gollapudi, {Sashi Kanth} and Tattikota, {Sudhir Gopal} and Shyam Mohan and Hariprasad Padhukasahasram and Yashwanth Subbannayya and Renu Goel and Jacob, {Harrys K.C.} and Jun Zhong and Raja Sekhar and Vishalakshi Nanjappa and Lavanya Balakrishnan and Roopashree Subbaiah and Ramachandra, {Y. L.} and {Abdul Rahiman}, B. and {Keshava Prasad}, {T. S.} and Lin, {Jian Xin} and Houtman, {Jon C.D.} and Stephen Desiderio and Renauld, {Jean Christophe} and Stefan Constantinescu and Osamu Ohara and Toshio Hirano and Masato Kubo and Sujay Singh and Purvesh Khatri and Sorin Draghici and Bader, {Gary D.} and Chris Sander and Leonard, {Warren J.} and Akhilesh Pandey",

note = "Funding Information: Akhilesh Pandey is supported by grants from Johns Hopkins Breast Cancer SPORE (CA 88843) Career Development Award, Department of Defense Era of Hope Scholar (W81XWH-06-1-0428) and partly by National Institutes of Health grant U54 RR020839 (Roadmap Initiative for Technology Centers for Networks and Pathways).",

year = "2010",

month = jan,

day = "12",

doi = "10.1186/gb-2010-11-1-r3",

language = "English (US)",

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Kandasamy, K, Sujatha Mohan, S, Raju, R, Keerthikumar, S, Sameer Kumar, GS, Venugopal, AK, Telikicherla, D, Navarro, DJ, Mathivanan, S, Pecquet, C, Gollapudi, SK, Tattikota, SG, Mohan, S, Padhukasahasram, H, Subbannayya, Y, Goel, R, Jacob, HKC, Zhong, J, Sekhar, R, Nanjappa, V, Balakrishnan, L, Subbaiah, R, Ramachandra, YL, Abdul Rahiman, B, Keshava Prasad, TS, Lin, JX, Houtman, JCD, Desiderio, S, Renauld, JC, Constantinescu, S, Ohara, O, Hirano, T, Kubo, M, Singh, S, Khatri, P, Draghici, S, Bader, GD, Sander, C, Leonard, WJ & Pandey, A 2010, 'NetPath: A public resource of curated signal transduction pathways', Genome biology, vol. 11, no. 1, r3. https://doi.org/10.1186/gb-2010-11-1-r3

TY - JOUR

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T2 - A public resource of curated signal transduction pathways

AU - Kandasamy, Kumaran

AU - Sujatha Mohan, S.

AU - Raju, Rajesh

AU - Keerthikumar, Shivakumar

AU - Sameer Kumar, Ghantasala S.

AU - Venugopal, Abhilash K.

AU - Telikicherla, Deepthi

AU - Navarro, Daniel J.

AU - Mathivanan, Suresh

AU - Pecquet, Christian

AU - Gollapudi, Sashi Kanth

AU - Tattikota, Sudhir Gopal

AU - Mohan, Shyam

AU - Padhukasahasram, Hariprasad

AU - Subbannayya, Yashwanth

AU - Goel, Renu

AU - Jacob, Harrys K.C.

AU - Zhong, Jun

AU - Sekhar, Raja

AU - Nanjappa, Vishalakshi

AU - Balakrishnan, Lavanya

AU - Subbaiah, Roopashree

AU - Ramachandra, Y. L.

AU - Abdul Rahiman, B.

AU - Keshava Prasad, T. S.

AU - Lin, Jian Xin

AU - Houtman, Jon C.D.

AU - Desiderio, Stephen

AU - Renauld, Jean Christophe

AU - Constantinescu, Stefan

AU - Ohara, Osamu

AU - Hirano, Toshio

AU - Kubo, Masato

AU - Singh, Sujay

AU - Khatri, Purvesh

AU - Draghici, Sorin

AU - Bader, Gary D.

AU - Sander, Chris

AU - Leonard, Warren J.

AU - Pandey, Akhilesh

N1 - Funding Information: Akhilesh Pandey is supported by grants from Johns Hopkins Breast Cancer SPORE (CA 88843) Career Development Award, Department of Defense Era of Hope Scholar (W81XWH-06-1-0428) and partly by National Institutes of Health grant U54 RR020839 (Roadmap Initiative for Technology Centers for Networks and Pathways).

PY - 2010/1/12

Y1 - 2010/1/12

N2 - We have developed NetPath as a resource of curated human signaling pathways. As an initial step, NetPath provides detailed maps of a number of immune signaling pathways, which include ~1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally-regulated genes - all linked to over 5,500 published articles. We anticipate NetPath to become a consolidated resource for human signaling pathways that should enable systems biology approaches.

AB - We have developed NetPath as a resource of curated human signaling pathways. As an initial step, NetPath provides detailed maps of a number of immune signaling pathways, which include ~1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally-regulated genes - all linked to over 5,500 published articles. We anticipate NetPath to become a consolidated resource for human signaling pathways that should enable systems biology approaches.

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U2 - 10.1186/gb-2010-11-1-r3

DO - 10.1186/gb-2010-11-1-r3

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AN - SCOPUS:77349091815

SN - 1474-7596

VL - 11

JO - Genome Biology

JF - Genome Biology

IS - 1

M1 - r3

ER -

NetPath: A public resource of curated signal transduction pathways

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