Network analysis of protein dynamics

Csaba Böde, István A. Kovács, Máté S. Szalay, Robin Palotai, Tamás Korcsmáros, Péter Csermely*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

159 Scopus citations

Abstract

The network paradigm is increasingly used to describe the topology and dynamics of complex systems. Here, we review the results of the topological analysis of protein structures as molecular networks describing their small-world character, and the role of hubs and central network elements in governing enzyme activity, allosteric regulation, protein motor function, signal transduction and protein stability. We summarize available data how central network elements are enriched in active centers and ligand binding sites directing the dynamics of the entire protein. We assess the feasibility of conformational and energy networks to simplify the vast complexity of rugged energy landscapes and to predict protein folding and dynamics. Finally, we suggest that modular analysis, novel centrality measures, hierarchical representation of networks and the analysis of network dynamics will soon lead to an expansion of this field.

Original languageEnglish (US)
Pages (from-to)2776-2782
Number of pages7
JournalFEBS Letters
Volume581
Issue number15
DOIs
StatePublished - Jun 19 2007

Keywords

  • Allosteric regulation
  • Disordered proteins
  • Enzyme catalysis
  • Molecular machines
  • Motions
  • Network topology
  • Protein structure
  • Signal transduction
  • Small-world
  • Water

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint Dive into the research topics of 'Network analysis of protein dynamics'. Together they form a unique fingerprint.

Cite this