Network-targeted stimulation engages neurobehavioral hallmarks of age-related memory decline

Aneesha S. Nilakantan, M. Marsel Mesulam, Sandra Weintraub, Erica L. Karp, Stephen Vanhaerents, Joel L. Voss*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

ObjectiveTo test whether targeting hippocampal-cortical brain networks with high-frequency transcranial magnetic stimulation in older adults influences behavioral and neural measures characteristic of age-related memory impairment.MethodsFifteen adults aged 64 to 80 years (mean = 72 years) completed a single-blind, sham-controlled experiment. Stimulation targets in parietal cortex were determined based on fMRI connectivity with the hippocampus. Recollection and recognition memory were assessed after 5 consecutive daily sessions of full-intensity stimulation vs low-intensity sham stimulation using a within-subjects crossover design. Neural correlates of recollection and recognition memory formation were obtained via fMRI, measured within the targeted hippocampal-cortical network vs a control frontal-parietal network. These outcomes were measured approximately 24 hours after the final stimulation session.ResultsRecollection was specifically impaired in older adults compared to a young-adult control sample at baseline. Relative to sham, stimulation improved recollection to a greater extent than recognition. Stimulation increased recollection fMRI signals throughout the hippocampal-cortical network, including at the targeted location of the hippocampus. Effects of stimulation on fMRI recollection signals were greater than those for recognition and were greater in the targeted network compared to the control network.ConclusionsAge-related recollection impairments were causally related to hippocampal-cortical network function in older adults. Stimulation selectively modified neural and behavioral hallmarks of age-related memory impairment, indicating effective engagement of memory intervention targets in older adults.

Original languageEnglish (US)
Pages (from-to)E2349-E2354
JournalNeurology
Volume92
Issue number20
DOIs
StatePublished - May 14 2019

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Magnetic Resonance Imaging
Hippocampus
Parietal Lobe
Transcranial Magnetic Stimulation
Cross-Over Studies
Young Adult
Recognition (Psychology)
Brain

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

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title = "Network-targeted stimulation engages neurobehavioral hallmarks of age-related memory decline",
abstract = "ObjectiveTo test whether targeting hippocampal-cortical brain networks with high-frequency transcranial magnetic stimulation in older adults influences behavioral and neural measures characteristic of age-related memory impairment.MethodsFifteen adults aged 64 to 80 years (mean = 72 years) completed a single-blind, sham-controlled experiment. Stimulation targets in parietal cortex were determined based on fMRI connectivity with the hippocampus. Recollection and recognition memory were assessed after 5 consecutive daily sessions of full-intensity stimulation vs low-intensity sham stimulation using a within-subjects crossover design. Neural correlates of recollection and recognition memory formation were obtained via fMRI, measured within the targeted hippocampal-cortical network vs a control frontal-parietal network. These outcomes were measured approximately 24 hours after the final stimulation session.ResultsRecollection was specifically impaired in older adults compared to a young-adult control sample at baseline. Relative to sham, stimulation improved recollection to a greater extent than recognition. Stimulation increased recollection fMRI signals throughout the hippocampal-cortical network, including at the targeted location of the hippocampus. Effects of stimulation on fMRI recollection signals were greater than those for recognition and were greater in the targeted network compared to the control network.ConclusionsAge-related recollection impairments were causally related to hippocampal-cortical network function in older adults. Stimulation selectively modified neural and behavioral hallmarks of age-related memory impairment, indicating effective engagement of memory intervention targets in older adults.",
author = "Nilakantan, {Aneesha S.} and Mesulam, {M. Marsel} and Sandra Weintraub and Karp, {Erica L.} and Stephen Vanhaerents and Voss, {Joel L.}",
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Network-targeted stimulation engages neurobehavioral hallmarks of age-related memory decline. / Nilakantan, Aneesha S.; Mesulam, M. Marsel; Weintraub, Sandra; Karp, Erica L.; Vanhaerents, Stephen; Voss, Joel L.

In: Neurology, Vol. 92, No. 20, 14.05.2019, p. E2349-E2354.

Research output: Contribution to journalArticle

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AU - Nilakantan, Aneesha S.

AU - Mesulam, M. Marsel

AU - Weintraub, Sandra

AU - Karp, Erica L.

AU - Vanhaerents, Stephen

AU - Voss, Joel L.

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