Neural correlates of anxiety in healthy volunteers: A voxel-based morphometry study

Maria Vittoria Spampinato, Jacqueline N. Wood, Veronica De Simone, Jordan Grafman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


Studies have shown that the amygdala, temporal, and prefrontal cortices play a key role in the expression of anxiety. The correlation between gray matter volume of these structures and behavioral anxiety measures was not previously investigated in healthy volunteers. The authors used voxel-based morphometry to assess the relationship between brain regional volume and anxiety. The authors found an inverse correlation between anxiety measures and cortical volume in regions of the limbic system and prefrontal cortex implicated in the pathogenesis of anxiety disorders. The authors suggest that volumetric variability of these regions may have a correlation with the development of an anxious personality trait.

Original languageEnglish (US)
Pages (from-to)199-205
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number2
StatePublished - 2009

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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