Neural correlates of apathy revealed by lesion mapping in participants with traumatic brain injuries

Kristine M. Knutson, Olga Dal Monte, Vanessa Raymont, Eric M. Wassermann, Frank Krueger, Jordan Henry Grafman*

*Corresponding author for this work

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Apathy, common in neurological disorders, is defined as disinterest and loss of motivation, with a reduction in self-initiated activity. Research in diseased populations has shown that apathy is associated with variations in the volume of brain regions such as the anterior cingulate and the frontal lobes. The goal of this study was to determine the neural signatures of apathy in people with penetrating traumatic brain injuries (pTBIs), as to our knowledge, these have not been studied in this sample. We studied 176 male Vietnam War veterans with pTBIs using voxel-based lesion-symptom mapping (VLSM) and apathy scores from the UCLA Neuropsychiatric Inventory (NPI), a structured inventory of symptoms completed by a caregiver. Our results revealed that increased apathy symptoms were associated with brain damage in limbic and cortical areas of the left hemisphere including the anterior cingulate, inferior, middle, and superior frontal regions, insula, and supplementary motor area. Our results are consistent with the literature, and extend them to people with focal pTBI. Apathy is a significant symptom since it can reduce participation of the patient in family and other social interactions, and diminish affective decision-making.

Original languageEnglish (US)
Pages (from-to)943-953
Number of pages11
JournalHuman Brain Mapping
Volume35
Issue number3
DOIs
StatePublished - Mar 1 2014

Fingerprint

Apathy
Penetrating Head Injuries
Gyrus Cinguli
Patient Participation
Equipment and Supplies
Vietnam
Motor Cortex
Brain
Frontal Lobe
Veterans
Interpersonal Relations
Nervous System Diseases
Caregivers
Traumatic Brain Injury
Motivation
Decision Making
Research
Population

Keywords

  • Apathy
  • Cingulate cortex
  • Fatigue
  • Insula
  • Traumatic brain injury
  • Voxel-based lesion-symptom mapping

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Knutson, Kristine M. ; Monte, Olga Dal ; Raymont, Vanessa ; Wassermann, Eric M. ; Krueger, Frank ; Grafman, Jordan Henry. / Neural correlates of apathy revealed by lesion mapping in participants with traumatic brain injuries. In: Human Brain Mapping. 2014 ; Vol. 35, No. 3. pp. 943-953.
@article{0305539cb2254dc6a84b944c9a3f0a3f,
title = "Neural correlates of apathy revealed by lesion mapping in participants with traumatic brain injuries",
abstract = "Apathy, common in neurological disorders, is defined as disinterest and loss of motivation, with a reduction in self-initiated activity. Research in diseased populations has shown that apathy is associated with variations in the volume of brain regions such as the anterior cingulate and the frontal lobes. The goal of this study was to determine the neural signatures of apathy in people with penetrating traumatic brain injuries (pTBIs), as to our knowledge, these have not been studied in this sample. We studied 176 male Vietnam War veterans with pTBIs using voxel-based lesion-symptom mapping (VLSM) and apathy scores from the UCLA Neuropsychiatric Inventory (NPI), a structured inventory of symptoms completed by a caregiver. Our results revealed that increased apathy symptoms were associated with brain damage in limbic and cortical areas of the left hemisphere including the anterior cingulate, inferior, middle, and superior frontal regions, insula, and supplementary motor area. Our results are consistent with the literature, and extend them to people with focal pTBI. Apathy is a significant symptom since it can reduce participation of the patient in family and other social interactions, and diminish affective decision-making.",
keywords = "Apathy, Cingulate cortex, Fatigue, Insula, Traumatic brain injury, Voxel-based lesion-symptom mapping",
author = "Knutson, {Kristine M.} and Monte, {Olga Dal} and Vanessa Raymont and Wassermann, {Eric M.} and Frank Krueger and Grafman, {Jordan Henry}",
year = "2014",
month = "3",
day = "1",
doi = "10.1002/hbm.22225",
language = "English (US)",
volume = "35",
pages = "943--953",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
number = "3",

}

Neural correlates of apathy revealed by lesion mapping in participants with traumatic brain injuries. / Knutson, Kristine M.; Monte, Olga Dal; Raymont, Vanessa; Wassermann, Eric M.; Krueger, Frank; Grafman, Jordan Henry.

In: Human Brain Mapping, Vol. 35, No. 3, 01.03.2014, p. 943-953.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neural correlates of apathy revealed by lesion mapping in participants with traumatic brain injuries

AU - Knutson, Kristine M.

AU - Monte, Olga Dal

AU - Raymont, Vanessa

AU - Wassermann, Eric M.

AU - Krueger, Frank

AU - Grafman, Jordan Henry

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Apathy, common in neurological disorders, is defined as disinterest and loss of motivation, with a reduction in self-initiated activity. Research in diseased populations has shown that apathy is associated with variations in the volume of brain regions such as the anterior cingulate and the frontal lobes. The goal of this study was to determine the neural signatures of apathy in people with penetrating traumatic brain injuries (pTBIs), as to our knowledge, these have not been studied in this sample. We studied 176 male Vietnam War veterans with pTBIs using voxel-based lesion-symptom mapping (VLSM) and apathy scores from the UCLA Neuropsychiatric Inventory (NPI), a structured inventory of symptoms completed by a caregiver. Our results revealed that increased apathy symptoms were associated with brain damage in limbic and cortical areas of the left hemisphere including the anterior cingulate, inferior, middle, and superior frontal regions, insula, and supplementary motor area. Our results are consistent with the literature, and extend them to people with focal pTBI. Apathy is a significant symptom since it can reduce participation of the patient in family and other social interactions, and diminish affective decision-making.

AB - Apathy, common in neurological disorders, is defined as disinterest and loss of motivation, with a reduction in self-initiated activity. Research in diseased populations has shown that apathy is associated with variations in the volume of brain regions such as the anterior cingulate and the frontal lobes. The goal of this study was to determine the neural signatures of apathy in people with penetrating traumatic brain injuries (pTBIs), as to our knowledge, these have not been studied in this sample. We studied 176 male Vietnam War veterans with pTBIs using voxel-based lesion-symptom mapping (VLSM) and apathy scores from the UCLA Neuropsychiatric Inventory (NPI), a structured inventory of symptoms completed by a caregiver. Our results revealed that increased apathy symptoms were associated with brain damage in limbic and cortical areas of the left hemisphere including the anterior cingulate, inferior, middle, and superior frontal regions, insula, and supplementary motor area. Our results are consistent with the literature, and extend them to people with focal pTBI. Apathy is a significant symptom since it can reduce participation of the patient in family and other social interactions, and diminish affective decision-making.

KW - Apathy

KW - Cingulate cortex

KW - Fatigue

KW - Insula

KW - Traumatic brain injury

KW - Voxel-based lesion-symptom mapping

UR - http://www.scopus.com/inward/record.url?scp=84893765471&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893765471&partnerID=8YFLogxK

U2 - 10.1002/hbm.22225

DO - 10.1002/hbm.22225

M3 - Article

C2 - 23404730

AN - SCOPUS:84893765471

VL - 35

SP - 943

EP - 953

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 3

ER -