Neural correlates of apathy revealed by lesion mapping in participants with traumatic brain injuries

Kristine M. Knutson, Olga Dal Monte, Vanessa Raymont, Eric M. Wassermann, Frank Krueger, Jordan Grafman*

*Corresponding author for this work

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Apathy, common in neurological disorders, is defined as disinterest and loss of motivation, with a reduction in self-initiated activity. Research in diseased populations has shown that apathy is associated with variations in the volume of brain regions such as the anterior cingulate and the frontal lobes. The goal of this study was to determine the neural signatures of apathy in people with penetrating traumatic brain injuries (pTBIs), as to our knowledge, these have not been studied in this sample. We studied 176 male Vietnam War veterans with pTBIs using voxel-based lesion-symptom mapping (VLSM) and apathy scores from the UCLA Neuropsychiatric Inventory (NPI), a structured inventory of symptoms completed by a caregiver. Our results revealed that increased apathy symptoms were associated with brain damage in limbic and cortical areas of the left hemisphere including the anterior cingulate, inferior, middle, and superior frontal regions, insula, and supplementary motor area. Our results are consistent with the literature, and extend them to people with focal pTBI. Apathy is a significant symptom since it can reduce participation of the patient in family and other social interactions, and diminish affective decision-making.

Original languageEnglish (US)
Pages (from-to)943-953
Number of pages11
JournalHuman Brain Mapping
Volume35
Issue number3
DOIs
StatePublished - Mar 1 2014

Keywords

  • Apathy
  • Cingulate cortex
  • Fatigue
  • Insula
  • Traumatic brain injury
  • Voxel-based lesion-symptom mapping

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

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