Neural correlates of caregiver burden in cortical basal syndrome and frontotemporal dementia

K. M. Knutson, G. Zamboni, M. C. Tierney, J. Grafman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Aims: To determine areas of atrophy in patients that are associated with caregiver burden. Methods: We measured caregiver burden, dementia and neuropsychiatric scores in 22 patients with corticobasal syndrome (CBS) and 25 with frontotemporal dementia (FTD), and in 14 healthy controls. We used voxel-based morphometry to correlate caregiver burden with gray matter loss. Results: Increased dementia and behavioral disturbances contributed to higher burden scores in CBS patients, while behavioral disturbances alone significantly affected burden scores in frontal-variant FTD (FTD-fv) patients. In CBS patients, caregiver burden scores correlated with atrophy in left inferior and middle temporal gyri. Conclusions: Caregivers of FTD-fv patients had significantly higher burden scores than caregivers of CBS patients. Damage to areas important in semantic knowledge appears critical in increased burden for CBS caregivers.

Original languageEnglish (US)
Pages (from-to)467-474
Number of pages8
JournalDementia and Geriatric Cognitive Disorders
Issue number5
StatePublished - Nov 2008


  • Caregiver burden
  • Corticobasal syndrome
  • Frontotemporal dementia
  • Magnetic resonance imaging
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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