Neural correlates of imaginal aggressive behavior assessed by positron emission tomography in healthy subjects

P. Pietrini, M. Guazzelli, G. Basso, K. Jaffe, J. Grafman*

*Corresponding author for this work

Research output: Contribution to journalArticle

186 Citations (Scopus)

Abstract

Objective: Neurodegenerative or traumatic lesions of the frontal lobes often lead to abnormally aggressive behavior. The authors hypothesized that the imaginal evoking of scenarios involving aggressive behavior would be associated with a modulation of the functional activity in the human frontal cortex. Method: Regional cerebral blood flow (rCBF) determinations by positron emission tomography and psychophysiological measures of emotional responsivity were obtained in a group of 15 young healthy volunteers with good visual imagery abilities and no history of abnormal behavior while they imagined the same scenario with four variations involving emotionally neutral behavior and aggressive behavior. Results: Compared to the imagined neutral scenario, the imagined scenarios involving aggressive behavior were associated with significant emotional reactivity and rCBF reductions in the ventromedial prefrontal cortex, suggesting that a functional deactivation of this cortical area occurs when individuals respond to the elicting of imagined aggressive behavior. Conclusions: These results in healthy subjects further expand previous findings from animal and human studies by providing an in vivo functional demonstration of the involvement of the orbitofrontal cortex in the expression of aggressive behavior. They are also consistent with the hypothesis that a functional alteration of this cortical region may be present in individuals with pathological aggressive behavior.

Original languageEnglish (US)
Pages (from-to)1772-1781
Number of pages10
JournalAmerican Journal of Psychiatry
Volume157
Issue number11
DOIs
StatePublished - Nov 15 2000

Fingerprint

Positron-Emission Tomography
Healthy Volunteers
Cerebrovascular Circulation
Regional Blood Flow
Frontal Lobe
Prefrontal Cortex
Aptitude
Imagery (Psychotherapy)
Human Activities

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

@article{ff17a5903bcd41aaa229499129506897,
title = "Neural correlates of imaginal aggressive behavior assessed by positron emission tomography in healthy subjects",
abstract = "Objective: Neurodegenerative or traumatic lesions of the frontal lobes often lead to abnormally aggressive behavior. The authors hypothesized that the imaginal evoking of scenarios involving aggressive behavior would be associated with a modulation of the functional activity in the human frontal cortex. Method: Regional cerebral blood flow (rCBF) determinations by positron emission tomography and psychophysiological measures of emotional responsivity were obtained in a group of 15 young healthy volunteers with good visual imagery abilities and no history of abnormal behavior while they imagined the same scenario with four variations involving emotionally neutral behavior and aggressive behavior. Results: Compared to the imagined neutral scenario, the imagined scenarios involving aggressive behavior were associated with significant emotional reactivity and rCBF reductions in the ventromedial prefrontal cortex, suggesting that a functional deactivation of this cortical area occurs when individuals respond to the elicting of imagined aggressive behavior. Conclusions: These results in healthy subjects further expand previous findings from animal and human studies by providing an in vivo functional demonstration of the involvement of the orbitofrontal cortex in the expression of aggressive behavior. They are also consistent with the hypothesis that a functional alteration of this cortical region may be present in individuals with pathological aggressive behavior.",
author = "P. Pietrini and M. Guazzelli and G. Basso and K. Jaffe and J. Grafman",
year = "2000",
month = "11",
day = "15",
doi = "10.1176/appi.ajp.157.11.1772",
language = "English (US)",
volume = "157",
pages = "1772--1781",
journal = "American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "11",

}

Neural correlates of imaginal aggressive behavior assessed by positron emission tomography in healthy subjects. / Pietrini, P.; Guazzelli, M.; Basso, G.; Jaffe, K.; Grafman, J.

In: American Journal of Psychiatry, Vol. 157, No. 11, 15.11.2000, p. 1772-1781.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neural correlates of imaginal aggressive behavior assessed by positron emission tomography in healthy subjects

AU - Pietrini, P.

AU - Guazzelli, M.

AU - Basso, G.

AU - Jaffe, K.

AU - Grafman, J.

PY - 2000/11/15

Y1 - 2000/11/15

N2 - Objective: Neurodegenerative or traumatic lesions of the frontal lobes often lead to abnormally aggressive behavior. The authors hypothesized that the imaginal evoking of scenarios involving aggressive behavior would be associated with a modulation of the functional activity in the human frontal cortex. Method: Regional cerebral blood flow (rCBF) determinations by positron emission tomography and psychophysiological measures of emotional responsivity were obtained in a group of 15 young healthy volunteers with good visual imagery abilities and no history of abnormal behavior while they imagined the same scenario with four variations involving emotionally neutral behavior and aggressive behavior. Results: Compared to the imagined neutral scenario, the imagined scenarios involving aggressive behavior were associated with significant emotional reactivity and rCBF reductions in the ventromedial prefrontal cortex, suggesting that a functional deactivation of this cortical area occurs when individuals respond to the elicting of imagined aggressive behavior. Conclusions: These results in healthy subjects further expand previous findings from animal and human studies by providing an in vivo functional demonstration of the involvement of the orbitofrontal cortex in the expression of aggressive behavior. They are also consistent with the hypothesis that a functional alteration of this cortical region may be present in individuals with pathological aggressive behavior.

AB - Objective: Neurodegenerative or traumatic lesions of the frontal lobes often lead to abnormally aggressive behavior. The authors hypothesized that the imaginal evoking of scenarios involving aggressive behavior would be associated with a modulation of the functional activity in the human frontal cortex. Method: Regional cerebral blood flow (rCBF) determinations by positron emission tomography and psychophysiological measures of emotional responsivity were obtained in a group of 15 young healthy volunteers with good visual imagery abilities and no history of abnormal behavior while they imagined the same scenario with four variations involving emotionally neutral behavior and aggressive behavior. Results: Compared to the imagined neutral scenario, the imagined scenarios involving aggressive behavior were associated with significant emotional reactivity and rCBF reductions in the ventromedial prefrontal cortex, suggesting that a functional deactivation of this cortical area occurs when individuals respond to the elicting of imagined aggressive behavior. Conclusions: These results in healthy subjects further expand previous findings from animal and human studies by providing an in vivo functional demonstration of the involvement of the orbitofrontal cortex in the expression of aggressive behavior. They are also consistent with the hypothesis that a functional alteration of this cortical region may be present in individuals with pathological aggressive behavior.

UR - http://www.scopus.com/inward/record.url?scp=0033755815&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033755815&partnerID=8YFLogxK

U2 - 10.1176/appi.ajp.157.11.1772

DO - 10.1176/appi.ajp.157.11.1772

M3 - Article

VL - 157

SP - 1772

EP - 1781

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

SN - 0002-953X

IS - 11

ER -