Neural correlates of mystical experience

Irene Cristofori, Joseph Bulbulia, John H. Shaver, Marc Wilson, Frank Krueger, Jordan Grafman*

*Corresponding author for this work

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Mystical experiences, or subjectively believed encounters with a supernatural world, are widely reported across cultures and throughout human history. Previous theories speculate that executive brain functions underpin mystical experiences. To evaluate causal hypotheses, structural studies of brain lesion are required. Previous studies suffer from small samples or do not have valid measures of cognitive functioning prior to injury. We investigated mystical experience among participants from the Vietnam Head Injury Study and compared those who suffered penetrating traumatic brain injury (pTBI; n=116) with matched healthy controls (HC; n=32). Voxel-based lesion-symptom mapping analysis showed that lesions to frontal and temporal brain regions were linked with greater mystical experiences. Such regions included the dorsolateral prefrontal cortex (dlPFC) and middle/superior temporal cortex (TC). In a confirmatory analysis, we grouped pTBI patients by lesion location and compared mysticism experiences with the HC group. The dlPFC group presented markedly increased mysticism. Notably, longitudinal analysis of pre-injury data (correlating with general intelligence and executive performance) excludes explanations from individual differences. Our findings support previous speculation linking executive brain functions to mystical experiences, and reveal that executive functioning (dlPFC) causally contributes to the down-regulation of mystical experiences.

Original languageEnglish (US)
Pages (from-to)212-220
Number of pages9
JournalNeuropsychologia
Volume80
DOIs
StatePublished - Jan 8 2016

Keywords

  • Mystical experience
  • Penetrating traumatic brain injuries
  • Religious belief
  • Voxel-based lesion-symptom mapping

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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    Cristofori, I., Bulbulia, J., Shaver, J. H., Wilson, M., Krueger, F., & Grafman, J. (2016). Neural correlates of mystical experience. Neuropsychologia, 80, 212-220. https://doi.org/10.1016/j.neuropsychologia.2015.11.021