Neural correlates of preserved facial affect perception in high functioning schizophrenia

Tatiana M. Karpouzian, Matthew P. Schroeder, Samantha V. Abram, Harry Wanar, Eva C. Alden, Shaun M. Eack, John G. Csernansky, Matthew J. Smith*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Individuals with ‘high functioning’ schizophrenia (HF-SCZ) may have preserved facial affect perception (FAP) compared to individuals with ‘low functioning’ schizophrenia (LF-SCZ). The neural mechanisms supporting preserved FAP in HF-SCZ have yet to be evaluated. This study compared brain activation during FAP performance in HF-SCZ, LF-SCZ, and controls. Results demonstrated greater activation in the precuneus in CON compared to both SCZ groups, while HF-SCZ activated this region intermediate to controls and LF-SCZ. These preliminary findings suggest greater precuneus activation may be related to preserved FAP in HF-SCZ compared to LF-SCZ, though future research is needed to further evaluate differences between groups.

Original languageEnglish (US)
Pages (from-to)83-85
Number of pages3
JournalPsychiatry Research - Neuroimaging
StatePublished - Aug 30 2017


  • Community functioning
  • Facial accept perception
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)


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