Neural development of selective attention and response inhibition

James R. Booth*, Douglas D. Burman, Joel R. Meyer, Zhang Lei, Barbara L. Trommer, Nicholas D. Davenport, Wei Li, Todd B. Parrish, Darren R. Gitelman, M. Marsel Mesulam

*Corresponding author for this work

Research output: Contribution to journalArticle

249 Scopus citations

Abstract

Brain activation differences between 12 children (9- to 12-year-olds) and 12 adults (20- to 30-year-olds) were examined on two cognitive tasks during functional magnetic resonance imaging (fMRI). Spatial selective attention was measured with the visual search for a conjunction target (red triangle) in a field of distracters and response inhibition was measured with a go no-go task. There were small developmental differences in the selective attention task, with children showing greater activation than adults in the anterior cingulate and thalamus. There were large developmental differences in the response inhibition task, with children showing greater activation than adults in a fronto-striatal network including middle cingulate, medial frontal gyrus, medial aspects of bilateral superior frontal gyrus, and the caudate nucleus on the left. Children also showed greater bilateral activation for the response inhibition task in posterior cingulate, thalamus and the hippocampo-amygdaloid region. The extensive developmental differences on the response inhibition task are consistent with the prolonged maturation of the fronto-striatal network.

Original languageEnglish (US)
Pages (from-to)737-751
Number of pages15
JournalNeuroimage
Volume20
Issue number2
DOIs
StatePublished - Oct 1 2003

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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    Booth, J. R., Burman, D. D., Meyer, J. R., Lei, Z., Trommer, B. L., Davenport, N. D., Li, W., Parrish, T. B., Gitelman, D. R., & Mesulam, M. M. (2003). Neural development of selective attention and response inhibition. Neuroimage, 20(2), 737-751. https://doi.org/10.1016/S1053-8119(03)00404-X