Neural plasticity and treatment-induced recovery of sentence processing in agrammatism

Cynthia K Thompson, Dirk Bart den Ouden, Borna Bonakdarpour, Kyla Garibaldi, Todd B Parrish

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

This study examined patterns of neural activation associated with treatment-induced improvement of complex sentence production (and comprehension) in six individuals with stroke-induced agrammatic aphasia, taking into account possible alterations in blood flow often associated with stroke, including delayed time-to-peak of the hemodynamic response function (HRF) and hypoperfused tissue. Aphasic participants performed an auditory verification fMRI task, processing object cleft, subject cleft, and simple active sentences, prior to and following a course of Treatment of Underlying Forms (TUF; Thompson et al., 2003), a linguistically based approach for treating aphasic sentence deficits, which targeted object relative clause constructions. The patients also were scanned in a long-trials task to examine HRFs, to account for any local deviations resulting from stroke, and perfusion images were obtained to evaluate regions of hypoperfused tissue. Region-of-interest (ROI) analyses were conducted (bilaterally), modeling participant-specific local HRFs in left hemisphere areas activated by 12 healthy age-matched volunteers performing the same task, including the middle and inferior frontal gyri, precentral gyrus, middle and superior temporal gyri, and insula, and additional regions associated with complex syntactic processing, including the posterior perisylvian and superior parietal cortices. Results showed that, despite individual variation in activation differences from pre- to post-treatment scans in the aphasic participants, main-effects analyses revealed a general shift from left superior temporal activation to more posterior temporoparietal areas, bilaterally. Time-to-peak of these responses correlated negatively with blood flow, as measured with perfusion imaging.

Original languageEnglish (US)
Pages (from-to)3211-3227
Number of pages17
JournalNeuropsychologia
Volume48
Issue number11
DOIs
StatePublished - Sep 1 2010

Fingerprint

Broca Aphasia
Neuronal Plasticity
Stroke
Parietal Lobe
Perfusion Imaging
Aphasia
Frontal Lobe
Temporal Lobe
Prefrontal Cortex
Volunteers
Therapeutics
Perfusion
Hemodynamics
Magnetic Resonance Imaging

Keywords

  • Agrammatic aphasia
  • Brain lesion
  • FMRI
  • Stroke
  • Syntax
  • TUF

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

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abstract = "This study examined patterns of neural activation associated with treatment-induced improvement of complex sentence production (and comprehension) in six individuals with stroke-induced agrammatic aphasia, taking into account possible alterations in blood flow often associated with stroke, including delayed time-to-peak of the hemodynamic response function (HRF) and hypoperfused tissue. Aphasic participants performed an auditory verification fMRI task, processing object cleft, subject cleft, and simple active sentences, prior to and following a course of Treatment of Underlying Forms (TUF; Thompson et al., 2003), a linguistically based approach for treating aphasic sentence deficits, which targeted object relative clause constructions. The patients also were scanned in a long-trials task to examine HRFs, to account for any local deviations resulting from stroke, and perfusion images were obtained to evaluate regions of hypoperfused tissue. Region-of-interest (ROI) analyses were conducted (bilaterally), modeling participant-specific local HRFs in left hemisphere areas activated by 12 healthy age-matched volunteers performing the same task, including the middle and inferior frontal gyri, precentral gyrus, middle and superior temporal gyri, and insula, and additional regions associated with complex syntactic processing, including the posterior perisylvian and superior parietal cortices. Results showed that, despite individual variation in activation differences from pre- to post-treatment scans in the aphasic participants, main-effects analyses revealed a general shift from left superior temporal activation to more posterior temporoparietal areas, bilaterally. Time-to-peak of these responses correlated negatively with blood flow, as measured with perfusion imaging.",
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Neural plasticity and treatment-induced recovery of sentence processing in agrammatism. / Thompson, Cynthia K; den Ouden, Dirk Bart; Bonakdarpour, Borna; Garibaldi, Kyla; Parrish, Todd B.

In: Neuropsychologia, Vol. 48, No. 11, 01.09.2010, p. 3211-3227.

Research output: Contribution to journalArticle

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AU - den Ouden, Dirk Bart

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AU - Parrish, Todd B

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