Neural stimulation with optical radiation

C. P. Richter*, A. I. Matic, J. D. Wells, E. D. Jansen, J. T. Walsh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

115 Scopus citations

Abstract

This paper reviews the existing research on infrared neural stimulation, a means of artificially stimulating neurons that has been proposed as an alternative to electrical stimulation. Infrared neural stimulation (INS) is defined as the direct induction of an evoked potential in response to a transient targeted deposition of optical energy. The foremost advantage of using optical radiation for neural stimulation is its spatial resolution. Exogenously applied or trans-genetically synthesized fluorophores are not used to achieve stimulation. Here, current work on INS is presented for motor nerves, sensory nerves, central nervous system, and in vitro preparations. A discussion follows addressing the mechanism of INS and its potential use in neuroprostheses. A brief review of neural depolarization involving other optical methods is also presented. Topics covered include optical stimulation concurrent with electrical stimulation, optical stimulation using exogenous fluorophores, and optical stimulation by transgenic induction of light-gated ion channels.This paper reviews the existing research on infrared neural stimulation, a means of artificially stimulating neurons that has been proposed as an alternative to electrical stimulation. Infrared neural stimulation (INS) is defined as the direct induction of an evoked potential in response to a transient targeted deposition of optical energy. The foremost advantage of using optical radiation for neural stimulation is its spatial resolution. Here, current work on INS is presented for motor nerves, sensory nerves, central nervous system, and in vitro preparations.

Original languageEnglish (US)
Pages (from-to)68-80
Number of pages13
JournalLaser and Photonics Reviews
Volume5
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • Cochlea
  • Cochlear implants
  • Deafening
  • Electrical stimulation
  • Infrared neural stimulation
  • Laser
  • Neuroprosthesis
  • Optical stimulation
  • Spatial selectivity.

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'Neural stimulation with optical radiation'. Together they form a unique fingerprint.

Cite this