Neural substrates of negativity bias in women with and without major depression

Jackie K. Gollan*, Megan Connolly, Angel Buchanan, Denada Hoxha, Laina Rosebrock, John Cacioppo, John Csernansky, Xue Wang

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background: The functional localization of negativity bias, an influential index of emotion information processing, has yet to be identified. Method: Depressed (n= 47) and healthy participants (n= 58) completed a clinical interview for DSM-IV Axis I disorders, symptom checklists, a behavioral task to measure negativity bias, and then viewed positive and negative images of social and nonsocial scenes during an event-related fMRI task. Two subsamples of participants with high (i.e., 75%; n= 26) and low (i.e., 25%; n= 26) negativity bias scores were as included in subsequent analyses to examine neural differences. Results: Depressed participants with a higher, relative to lower, negative bias showed significantly greater neural activation in the left inferior frontal gyrus. Conclusion: High negativity bias evokes a distinctive pattern of brain activation in the frontal cortex of depressed participants. Increased activation occurred in the left inferior frontal gyrus, related to Brodmann area 44, which is associated with language and semantic processing, response inhibition, and cognitive reappraisal. This finding may reflect an abnormality in integrative emotional processing rather than processing of individual emotional dimensions in depressed participants with negativity bias.

Original languageEnglish (US)
Pages (from-to)184-191
Number of pages8
JournalBiological Psychology
Volume109
DOIs
StatePublished - Jul 1 2015

Keywords

  • Affective reactivity
  • Major depression
  • Negativity bias
  • Neural activation
  • Valence

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

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