Neuro-QOL: Brief measures of health-related quality of life for clinical research in neurology

D. Cella*, J. S. Lai, C. J. Nowinski, D. Victorson, A. Peterman, D. Miller, F. Bethoux, A. Heinemann, S. Rubin, J. E. Cavazos, A. T. Reder, R. Sufit, T. Simuni, G. L. Holmes, A. Siderowf, V. Wojna, R. Bode, N. McKinney, T. Podrabsky, K. WortmanS. Choi, R. Gershon, N. Rothrock, C. Moy

*Corresponding author for this work

Research output: Contribution to journalArticle

153 Citations (Scopus)

Abstract

Objective: To address the need for brief, reliable, valid, and standardized quality of life (QOL) assessment applicable across neurologic conditions. Methods: Drawing from larger calibrated item banks, we developed short measures (8-9 items each) of 13 different QOL domains across physical, mental, and social health and evaluated their validity and reliability. Three samples were utilized during short form development: general population (Internet-based, n = 2,113); clinical panel (Internet-based, n = 553); and clinical outpatient (clinic-based, n=581). All short forms are expressed as T scores with a mean of 50 and SD of 10. Results: Internal consistency (Cronbach α) of the 13 short forms ranged from 0.85 to 0.97. Correlations between short form and full-length item bank scores ranged from 0.88 to 0.99 (0.82- 0.96 after removing common items from banks). Online respondents were asked whether they had any of 19 different chronic health conditions, and whether or not those reported conditions interfered with ability to function normally. All short forms, across physical, mental, and social health, were able to separate people who reported no health condition from those who reported 1-2 or 3 or more. In addition, scores on all 13 domains were worse for people who acknowledged being limited by the health conditions they reported, compared to those who reported conditions but were not limited by them.Conclusion: These 13 brief measures of self-reported QOL are reliable and show preliminary evidence of concurrent validity inasmuch as they differentiate people based upon number of reported health conditions and whether those reported conditions impede normal function.

Original languageEnglish (US)
Pages (from-to)1860-1867
Number of pages8
JournalNeurology
Volume78
Issue number23
DOIs
StatePublished - Jun 5 2012

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Neurology
Quality of Life
Health
Research
Internet
Mental Health
Aptitude
Ambulatory Care Facilities
Reproducibility of Results
Nervous System
Population

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Cella, D. ; Lai, J. S. ; Nowinski, C. J. ; Victorson, D. ; Peterman, A. ; Miller, D. ; Bethoux, F. ; Heinemann, A. ; Rubin, S. ; Cavazos, J. E. ; Reder, A. T. ; Sufit, R. ; Simuni, T. ; Holmes, G. L. ; Siderowf, A. ; Wojna, V. ; Bode, R. ; McKinney, N. ; Podrabsky, T. ; Wortman, K. ; Choi, S. ; Gershon, R. ; Rothrock, N. ; Moy, C. / Neuro-QOL : Brief measures of health-related quality of life for clinical research in neurology. In: Neurology. 2012 ; Vol. 78, No. 23. pp. 1860-1867.
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abstract = "Objective: To address the need for brief, reliable, valid, and standardized quality of life (QOL) assessment applicable across neurologic conditions. Methods: Drawing from larger calibrated item banks, we developed short measures (8-9 items each) of 13 different QOL domains across physical, mental, and social health and evaluated their validity and reliability. Three samples were utilized during short form development: general population (Internet-based, n = 2,113); clinical panel (Internet-based, n = 553); and clinical outpatient (clinic-based, n=581). All short forms are expressed as T scores with a mean of 50 and SD of 10. Results: Internal consistency (Cronbach α) of the 13 short forms ranged from 0.85 to 0.97. Correlations between short form and full-length item bank scores ranged from 0.88 to 0.99 (0.82- 0.96 after removing common items from banks). Online respondents were asked whether they had any of 19 different chronic health conditions, and whether or not those reported conditions interfered with ability to function normally. All short forms, across physical, mental, and social health, were able to separate people who reported no health condition from those who reported 1-2 or 3 or more. In addition, scores on all 13 domains were worse for people who acknowledged being limited by the health conditions they reported, compared to those who reported conditions but were not limited by them.Conclusion: These 13 brief measures of self-reported QOL are reliable and show preliminary evidence of concurrent validity inasmuch as they differentiate people based upon number of reported health conditions and whether those reported conditions impede normal function.",
author = "D. Cella and Lai, {J. S.} and Nowinski, {C. J.} and D. Victorson and A. Peterman and D. Miller and F. Bethoux and A. Heinemann and S. Rubin and Cavazos, {J. E.} and Reder, {A. T.} and R. Sufit and T. Simuni and Holmes, {G. L.} and A. Siderowf and V. Wojna and R. Bode and N. McKinney and T. Podrabsky and K. Wortman and S. Choi and R. Gershon and N. Rothrock and C. Moy",
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Cella, D, Lai, JS, Nowinski, CJ, Victorson, D, Peterman, A, Miller, D, Bethoux, F, Heinemann, A, Rubin, S, Cavazos, JE, Reder, AT, Sufit, R, Simuni, T, Holmes, GL, Siderowf, A, Wojna, V, Bode, R, McKinney, N, Podrabsky, T, Wortman, K, Choi, S, Gershon, R, Rothrock, N & Moy, C 2012, 'Neuro-QOL: Brief measures of health-related quality of life for clinical research in neurology', Neurology, vol. 78, no. 23, pp. 1860-1867. https://doi.org/10.1212/WNL.0b013e318258f744

Neuro-QOL : Brief measures of health-related quality of life for clinical research in neurology. / Cella, D.; Lai, J. S.; Nowinski, C. J.; Victorson, D.; Peterman, A.; Miller, D.; Bethoux, F.; Heinemann, A.; Rubin, S.; Cavazos, J. E.; Reder, A. T.; Sufit, R.; Simuni, T.; Holmes, G. L.; Siderowf, A.; Wojna, V.; Bode, R.; McKinney, N.; Podrabsky, T.; Wortman, K.; Choi, S.; Gershon, R.; Rothrock, N.; Moy, C.

In: Neurology, Vol. 78, No. 23, 05.06.2012, p. 1860-1867.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neuro-QOL

T2 - Brief measures of health-related quality of life for clinical research in neurology

AU - Cella, D.

AU - Lai, J. S.

AU - Nowinski, C. J.

AU - Victorson, D.

AU - Peterman, A.

AU - Miller, D.

AU - Bethoux, F.

AU - Heinemann, A.

AU - Rubin, S.

AU - Cavazos, J. E.

AU - Reder, A. T.

AU - Sufit, R.

AU - Simuni, T.

AU - Holmes, G. L.

AU - Siderowf, A.

AU - Wojna, V.

AU - Bode, R.

AU - McKinney, N.

AU - Podrabsky, T.

AU - Wortman, K.

AU - Choi, S.

AU - Gershon, R.

AU - Rothrock, N.

AU - Moy, C.

PY - 2012/6/5

Y1 - 2012/6/5

N2 - Objective: To address the need for brief, reliable, valid, and standardized quality of life (QOL) assessment applicable across neurologic conditions. Methods: Drawing from larger calibrated item banks, we developed short measures (8-9 items each) of 13 different QOL domains across physical, mental, and social health and evaluated their validity and reliability. Three samples were utilized during short form development: general population (Internet-based, n = 2,113); clinical panel (Internet-based, n = 553); and clinical outpatient (clinic-based, n=581). All short forms are expressed as T scores with a mean of 50 and SD of 10. Results: Internal consistency (Cronbach α) of the 13 short forms ranged from 0.85 to 0.97. Correlations between short form and full-length item bank scores ranged from 0.88 to 0.99 (0.82- 0.96 after removing common items from banks). Online respondents were asked whether they had any of 19 different chronic health conditions, and whether or not those reported conditions interfered with ability to function normally. All short forms, across physical, mental, and social health, were able to separate people who reported no health condition from those who reported 1-2 or 3 or more. In addition, scores on all 13 domains were worse for people who acknowledged being limited by the health conditions they reported, compared to those who reported conditions but were not limited by them.Conclusion: These 13 brief measures of self-reported QOL are reliable and show preliminary evidence of concurrent validity inasmuch as they differentiate people based upon number of reported health conditions and whether those reported conditions impede normal function.

AB - Objective: To address the need for brief, reliable, valid, and standardized quality of life (QOL) assessment applicable across neurologic conditions. Methods: Drawing from larger calibrated item banks, we developed short measures (8-9 items each) of 13 different QOL domains across physical, mental, and social health and evaluated their validity and reliability. Three samples were utilized during short form development: general population (Internet-based, n = 2,113); clinical panel (Internet-based, n = 553); and clinical outpatient (clinic-based, n=581). All short forms are expressed as T scores with a mean of 50 and SD of 10. Results: Internal consistency (Cronbach α) of the 13 short forms ranged from 0.85 to 0.97. Correlations between short form and full-length item bank scores ranged from 0.88 to 0.99 (0.82- 0.96 after removing common items from banks). Online respondents were asked whether they had any of 19 different chronic health conditions, and whether or not those reported conditions interfered with ability to function normally. All short forms, across physical, mental, and social health, were able to separate people who reported no health condition from those who reported 1-2 or 3 or more. In addition, scores on all 13 domains were worse for people who acknowledged being limited by the health conditions they reported, compared to those who reported conditions but were not limited by them.Conclusion: These 13 brief measures of self-reported QOL are reliable and show preliminary evidence of concurrent validity inasmuch as they differentiate people based upon number of reported health conditions and whether those reported conditions impede normal function.

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U2 - 10.1212/WNL.0b013e318258f744

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