TY - JOUR
T1 - Neuroanatomical asymmetry patterns in individuals with schizophrenia and their non-psychotic siblings
AU - Qiu, Anqi
AU - Wang, Lei
AU - Younes, Laurent
AU - Harms, Michael P.
AU - Ratnanather, J. Tilak
AU - Miller, Michael I.
AU - Csernansky, John G.
N1 - Funding Information:
This work has not been presented at any meeting or journal. It was supported by National University of Singapore start-up grant R-397-000-058-133 (AQ), A⁎STAR SERC 082-101-0025 (AQ), A⁎STAR SICS-09/1/1/001 (AQ), and National Institute of Health grants: P50-MH071616 (JGC and MIM), R01-MH056584 (JGC), and P41-RR15241 (MIM).
PY - 2009/10/1
Y1 - 2009/10/1
N2 - Neuroanatomical endophenotypes may reveal insights into the processes by which genetic factors increase the risk of developing schizophrenia. To determine whether patterns of neuroanatomical asymmetries may be useful as schizophrenia-related endophenotypes, we compared patterns of structural asymmetries in patients with schizophrenia, healthy controls, and their respective siblings. The surfaces of the left and right amygdala, hippocampus, thalamus, caudate nucleus, putamen, globus pallidus, and nucleus accumbens were assessed in 40 pairs of healthy comparison controls (CON) and their siblings (CON-SIB) and 25 pairs of patients with schizophrenia (SCZ) and their siblings (SCZ-SIB) in magnetic resonance (MR) images using large deformation diffeomorphic metric mapping (LDDMM) and parallel transport techniques. The within-subject asymmetry deformation of each structure was first measured via LDDMM, and then translated to a global template via parallel transport for evaluation of the patterns of asymmetry both within and across siblings. Our results revealed that asymmetries observed in CON subjects occurred in the amygdala and the anterior segment of the hippocampus with more pronounced expansion deformation in the right-sided structures (R > L asymmetry) but not in the basal ganglia and thalamus. Disturbance in this pattern of asymmetries was observed in both SCZ and SCZ-SIB subjects. More specifically, exaggerations and reductions in the normative pattern of asymmetries were observed in the amygdala-hippocampus formation, basal ganglia, and thalamus. These altered patterns of asymmetries are present in subjects with schizophrenia and their siblings, and therefore may represent a schizophrenia-related endophenotype.
AB - Neuroanatomical endophenotypes may reveal insights into the processes by which genetic factors increase the risk of developing schizophrenia. To determine whether patterns of neuroanatomical asymmetries may be useful as schizophrenia-related endophenotypes, we compared patterns of structural asymmetries in patients with schizophrenia, healthy controls, and their respective siblings. The surfaces of the left and right amygdala, hippocampus, thalamus, caudate nucleus, putamen, globus pallidus, and nucleus accumbens were assessed in 40 pairs of healthy comparison controls (CON) and their siblings (CON-SIB) and 25 pairs of patients with schizophrenia (SCZ) and their siblings (SCZ-SIB) in magnetic resonance (MR) images using large deformation diffeomorphic metric mapping (LDDMM) and parallel transport techniques. The within-subject asymmetry deformation of each structure was first measured via LDDMM, and then translated to a global template via parallel transport for evaluation of the patterns of asymmetry both within and across siblings. Our results revealed that asymmetries observed in CON subjects occurred in the amygdala and the anterior segment of the hippocampus with more pronounced expansion deformation in the right-sided structures (R > L asymmetry) but not in the basal ganglia and thalamus. Disturbance in this pattern of asymmetries was observed in both SCZ and SCZ-SIB subjects. More specifically, exaggerations and reductions in the normative pattern of asymmetries were observed in the amygdala-hippocampus formation, basal ganglia, and thalamus. These altered patterns of asymmetries are present in subjects with schizophrenia and their siblings, and therefore may represent a schizophrenia-related endophenotype.
KW - Large deformation diffeomorphic metric mapping
KW - Magnetic resonance imaging
KW - Parallel transport
KW - Schizophrenia
KW - Shape asymmetry
KW - Siblings
KW - Subcortical structures
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U2 - 10.1016/j.neuroimage.2009.05.054
DO - 10.1016/j.neuroimage.2009.05.054
M3 - Article
C2 - 19481156
AN - SCOPUS:67651064327
SN - 1053-8119
VL - 47
SP - 1221
EP - 1229
JO - NeuroImage
JF - NeuroImage
IS - 4
ER -