Neurobehavioral Biomarkers: An EEG Family Reunion

Joshua B. Ewen*, April R. Levin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


The field of clinical EEG has had an uneasy relationship with the use of this technology for clinical cognitive applications and often for good reason. However, apart from its clinical use, EEG has had a tradition as a major tool in cognitive psychology and cognitive neuroscience dating back at least to the 1960s. Based on accumulated knowledge from its research application, EEG-based biomarkers are beginning to see applications in clinical trials and may eventually enter clinical care. We address concerns surrounding quality control, the treatment of artifact, and normal variants and how developments in engineering, biomarker validation, and implementation science rigorously applied to these tools can lead to well-justified approaches.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalJournal of Clinical Neurophysiology
Issue number2
StatePublished - Feb 1 2022


  • Biomarker
  • Cognitive neuroscience
  • EEG
  • History

ASJC Scopus subject areas

  • Physiology
  • Neurology
  • Clinical Neurology
  • Physiology (medical)


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