Neurobiological mechanisms of state-dependent learning

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

State-dependent learning (SDL) is a phenomenon relating to information storage and retrieval restricted to discrete states. While extensively studied using psychopharmacological approaches, SDL has not been subjected to rigorous neuroscientific study. Here we present an overview of approaches historically used to induce SDL, and highlight some of the known neurobiological mechanisms, in particular those related to inhibitory neurotransmission and its regulation by microRNAs (miR). We also propose novel cellular and circuit mechanisms as contributing factors. Lastly, we discuss the implications of advancing our knowledge on SDL, both for most fundamental processes of learning and memory as well as for development and maintenance of psychopathology.

Original languageEnglish (US)
Pages (from-to)92-98
Number of pages7
JournalCurrent opinion in neurobiology
Volume45
DOIs
StatePublished - Aug 2017

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Learning
Information Storage and Retrieval
MicroRNAs
Psychopathology
Synaptic Transmission
Maintenance

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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title = "Neurobiological mechanisms of state-dependent learning",
abstract = "State-dependent learning (SDL) is a phenomenon relating to information storage and retrieval restricted to discrete states. While extensively studied using psychopharmacological approaches, SDL has not been subjected to rigorous neuroscientific study. Here we present an overview of approaches historically used to induce SDL, and highlight some of the known neurobiological mechanisms, in particular those related to inhibitory neurotransmission and its regulation by microRNAs (miR). We also propose novel cellular and circuit mechanisms as contributing factors. Lastly, we discuss the implications of advancing our knowledge on SDL, both for most fundamental processes of learning and memory as well as for development and maintenance of psychopathology.",
author = "Jelena Radulovic and Vladimir Jovasevic and Meyer, {Mariah AA}",
year = "2017",
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language = "English (US)",
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Neurobiological mechanisms of state-dependent learning. / Radulovic, Jelena; Jovasevic, Vladimir; Meyer, Mariah AA.

In: Current opinion in neurobiology, Vol. 45, 08.2017, p. 92-98.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Neurobiological mechanisms of state-dependent learning

AU - Radulovic, Jelena

AU - Jovasevic, Vladimir

AU - Meyer, Mariah AA

PY - 2017/8

Y1 - 2017/8

N2 - State-dependent learning (SDL) is a phenomenon relating to information storage and retrieval restricted to discrete states. While extensively studied using psychopharmacological approaches, SDL has not been subjected to rigorous neuroscientific study. Here we present an overview of approaches historically used to induce SDL, and highlight some of the known neurobiological mechanisms, in particular those related to inhibitory neurotransmission and its regulation by microRNAs (miR). We also propose novel cellular and circuit mechanisms as contributing factors. Lastly, we discuss the implications of advancing our knowledge on SDL, both for most fundamental processes of learning and memory as well as for development and maintenance of psychopathology.

AB - State-dependent learning (SDL) is a phenomenon relating to information storage and retrieval restricted to discrete states. While extensively studied using psychopharmacological approaches, SDL has not been subjected to rigorous neuroscientific study. Here we present an overview of approaches historically used to induce SDL, and highlight some of the known neurobiological mechanisms, in particular those related to inhibitory neurotransmission and its regulation by microRNAs (miR). We also propose novel cellular and circuit mechanisms as contributing factors. Lastly, we discuss the implications of advancing our knowledge on SDL, both for most fundamental processes of learning and memory as well as for development and maintenance of psychopathology.

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JO - Current Opinion in Neurobiology

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