Neurobiological mechanisms of state-dependent learning

Jelena Radulovic, Vladimir Jovasevic, Mariah AA Meyer

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

State-dependent learning (SDL) is a phenomenon relating to information storage and retrieval restricted to discrete states. While extensively studied using psychopharmacological approaches, SDL has not been subjected to rigorous neuroscientific study. Here we present an overview of approaches historically used to induce SDL, and highlight some of the known neurobiological mechanisms, in particular those related to inhibitory neurotransmission and its regulation by microRNAs (miR). We also propose novel cellular and circuit mechanisms as contributing factors. Lastly, we discuss the implications of advancing our knowledge on SDL, both for most fundamental processes of learning and memory as well as for development and maintenance of psychopathology.

Original languageEnglish (US)
Pages (from-to)92-98
Number of pages7
JournalCurrent opinion in neurobiology
Volume45
DOIs
StatePublished - Aug 2017

ASJC Scopus subject areas

  • Neuroscience(all)

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