Neurobiology of butyrylcholinesterase

Sultan Darvesh*, David A. Hopkins, Changiz Geula

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

738 Scopus citations


Butyrylcholinesterase is a serine hydrolase related to acetylcholinesterase that catalyses the hydrolysis of esters of choline, including acetylcholine. Butyrylcholinesterase has unique enzymatic properties and is widely distributed in the nervous system, pointing to its possible involvement in neural function. Here, we summarize the biochemical properties of butyrylcholinesterase and review the evidence that this enzyme has important roles in cholinergic neurotransmission and could be involved in other nervous system functions and in neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)131-138
Number of pages8
JournalNature Reviews Neuroscience
Issue number2
StatePublished - Feb 2003

ASJC Scopus subject areas

  • General Neuroscience


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