Neurobiology of butyrylcholinesterase

Sultan Darvesh; David A. Hopkins; Changiz Geula

doi:10.1038/nrn1035

Neurobiology of butyrylcholinesterase

Sultan Darvesh^*, David A. Hopkins, Changiz Geula

^*Corresponding author for this work

Mesulam Center for Cognitive Neurology and Alzheimers Disease

Research output: Contribution to journal › Article › peer-review

568 Scopus citations

Abstract

Butyrylcholinesterase is a serine hydrolase related to acetylcholinesterase that catalyses the hydrolysis of esters of choline, including acetylcholine. Butyrylcholinesterase has unique enzymatic properties and is widely distributed in the nervous system, pointing to its possible involvement in neural function. Here, we summarize the biochemical properties of butyrylcholinesterase and review the evidence that this enzyme has important roles in cholinergic neurotransmission and could be involved in other nervous system functions and in neurodegenerative diseases.

Original language	English (US)
Pages (from-to)	131-138
Number of pages	8
Journal	Nature Reviews Neuroscience
Volume	4
Issue number	2
DOIs	https://doi.org/10.1038/nrn1035
State	Published - Feb 2003

ASJC Scopus subject areas

Neuroscience(all)

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10.1038/nrn1035

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