Neurobiology of circadian rhythm regulation

Alan M. Rosenwasser*, Fred W. Turek

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Over the past few decades, multilevel research has elucidated the basic neuroanatomy, neurochemistry, and molecular neurobiology of the master circadian pacemaker located in the hypothalamic suprachiasmatic nucleus (SCN). The circadian timing system is composed of a large number of cellular oscillators located in the SCN, in non-SCN brain structures, and throughout the body. Cellular-level oscillations are generated by a molecular feedback loop in which circadian clock genes rhythmically regulate their own transcription, as well as that of hundreds of clock-controlled genes. The maintenance of proper coordination within this network of cellular- and tissue-level clocks is essential for health and well-being.

Original languageEnglish (US)
Pages (from-to)403-412
Number of pages10
JournalSleep Medicine Clinics
Volume10
Issue number4
DOIs
StatePublished - Dec 2015

Keywords

  • Circadian
  • Clock genes
  • Entrainment
  • Pacemaker
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

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