Neurobiology of circadian rhythm sleep disorders

Prasanth Manthena, Phyllis C. Zee*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


To adapt to a 24-hour environment, nearly all organisms, from mammals to single-celled organisms, have developed endogenous mechanisms that generate nearly 24-hour (circadian) rhythms in physiology and behavior, the most notable being that of the daily cycles of sleep and wake. Disruption of these circadian rhythms is often accompanied by disorders of sleep and wakefulness. With the recent advances in the molecular biology that underlies the development and maintenance of these rhythms, the pathophysiology behind circadian rhythm sleep disorders is becoming better understood.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalCurrent neurology and neuroscience reports
Issue number2
StatePublished - Mar 2006

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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