Neurobiology of sleep

Brandon S. Lu*, Phyllis C Zee

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


The neurobiology of sleep is introduced in the context of interacting wake and sleep systems. Specifically, the transitions from wake to sleep and from non-rapid eye movement to rapid eye movement sleep are discussed based on the flip-flop switch hypothesis. Regulation of wake and sleep according to the opposing homeostatic and circadian systems are also presented.

Original languageEnglish (US)
Pages (from-to)309-318
Number of pages10
JournalClinics in Chest Medicine
Issue number2
StatePublished - Jun 1 2010


  • Sleep disorders
  • Sleep neurobiology
  • Sleep regulation
  • Sleep-wake transition

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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