Neuroblastoma Arising in an Immature Teratoma of the Ovary in a 13-Year-Old

Christopher Felicelli, Jessica Gulliver, Corey Gray, Andrey Khramtsov, Luis Z. Blanco, Nitin R. Wadhwani*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Somatic malignancies arising in mature teratomas are exceedingly rare entities and even more so are those arising in immature teratomas. Here, we present a unique case of a 13-year-old who initially underwent ovarian sparing cystectomy for a 7.7 cm left ovarian mass with a pre-operative diagnosis of mature cystic teratoma. Histologically, all 3 germ cell layers were present and immature neuroepithelial tubules were also identified. Subsequent sections revealed a nodular lesion composed of neuropil, neuroblasts with a spectrum of maturation, and Schwannian-type stroma. The neuroblasts were diffusely positive for PHOX2B. Neuroblastoma arising in an immature teratoma has only been described in the literature once previously in an adult patient.

Original languageEnglish (US)
Pages (from-to)72-76
Number of pages5
JournalPediatric and Developmental Pathology
Issue number1
StatePublished - Jan 1 2023


  • immature teratoma
  • malignant teratoma
  • neuroblastoma
  • ovarian teratoma
  • peripheral neuroblastic tumor in ovarian teratoma
  • somatic malignancy teratoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine


Dive into the research topics of 'Neuroblastoma Arising in an Immature Teratoma of the Ovary in a 13-Year-Old'. Together they form a unique fingerprint.

Cite this