Neurocognition and conversion to psychosis in adolescents at high-risk

D. J. Walder*, V. Mittal, H. D. Trotman, A. L. McMillan, E. F. Walker

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


This study examined neurocognitive predictors of conversion to Axis I psychosis among adolescents at high-risk for psychosis (AHRP). There were no significant differences in neurocognitive performance between adolescents at high-risk for psychosis who converted (AHRP+) and adolescents at high-risk for psychosis who did not convert (AHRP-). Within-sex comparisons revealed a relation between risk status and performance among females, with AHRP+ performing below AHRP-, but this effect did not hold for males. Between-sex comparisons revealed AHRP- males performed worse than AHRP- females on several measures. Across groups, males performed better than their female counterparts on select measures. Results are discussed in terms of implications for use of neurocognitive profiles as bio-risk markers of psychosis, while considering sex differences.

Original languageEnglish (US)
Pages (from-to)161-168
Number of pages8
JournalSchizophrenia Research
Issue number1-3
StatePublished - Apr 2008


  • Adolescents
  • Bio-risk markers
  • Cognition
  • High-risk
  • Psychosis
  • Sex differences

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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