Neurocognition with maraviroc compared with tenofovir in HIV

Kevin R. Robertson*, Sachiko Miyahara, Anthony Lee, Todd T. Brown, Ellen S. Chan, Baiba Berzins, David Rusin, Joseph J. Eron, Babafemi O. Taiwo

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Objective: The objective was to determine whether maraviroc (MVC) has unique neurocognitive benefits in the context of initial antiretroviral therapy (ART). Design: Randomized, double-blind, placebo-controlled, 48-week trial. Setting: Participants were enrolled in US AIDS Clinical Trials Group clinical trial sites. Participants: Total 262 ART-naive, chemokine coreceptor 5 tropic HIV, and HIV RNA greater than 1000 copies/ml participants were randomized, 230 participants completed the study. Intervention: Participants received MVC 150mg or tenofovir disoproxil fumarate (TDF) 300mg on a background of ritonavir-boosted darunavir and emtricitabine. Main outcome measure(s): The neuropsychological battery of 15 tests done at baseline, week 24 and week 48 assessed seven domains, and were standardized into z-scores then converted into deficit scores and a global deficit score. The 48-week changes from baseline in the neuropsychological scores and the global deficit score were compared by Wilcoxon or Kruskal-Wallis test between arms, and among baseline impairment groups [classified as normal, mild (2 deficit scores ≥1) and moderate (2 deficit scores ≥2)]. It was hypothesized that the MVC arm would have improved neuropsychological performance over TDF. Results: In this double-blind, randomized, placebo-controlled trial, there were no differences in neuropsychological performance between MVC and TDF. Those with moderate neuropsychological impairment at baseline experienced greater ARTmediated neuropsychological improvement than those with mild or no neuropsychological impairment. Conclusion: Improvement in neurocognitive functioning was greater with more baseline impairment but was comparable with MVC or TDF.

Original languageEnglish (US)
Pages (from-to)2315-2321
Number of pages7
JournalAIDS
Volume30
Issue number15
DOIs
StatePublished - Sep 24 2016

Keywords

  • HIV-associated neurocognitive disorders
  • central nervous system
  • maraviroc
  • neurocognitive
  • neuropathogenesis
  • tenofovir

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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  • Cite this

    Robertson, K. R., Miyahara, S., Lee, A., Brown, T. T., Chan, E. S., Berzins, B., Rusin, D., Eron, J. J., & Taiwo, B. O. (2016). Neurocognition with maraviroc compared with tenofovir in HIV. AIDS, 30(15), 2315-2321. https://doi.org/10.1097/QAD.0000000000001189