Neurocognitive sequelae of pediatric sickle cell disease: A review of the literature

Leslie D. Berkelhammer*, Adrienne L. Williamson, Stacy D. Sanford, Courtney L. Dirksen, William G. Sharp, Allison S. Margulies, Rebecca A. Prengler

*Corresponding author for this work

Research output: Contribution to journalReview article

91 Scopus citations

Abstract

This literature review summarizes all studies relating neuropsychological performance to neuroimaging findings in pediatric sickle cell disease (N=28; published 1991-2005). Although inconsistencies exist within and across domains, deficits in intelligence (IQ), attention and executive functions, memory, language, visuomotor abilities, and academic achievement have been identified. Overall neurocognitive compromise was revealed to be related to the level of neurological injury and the location of silent infarct. Attentional and executive dysfunction is prevalent and related to frontal lobe abnormalities.

Original languageEnglish (US)
Pages (from-to)120-131
Number of pages12
JournalChild Neuropsychology
Volume13
Issue number2
DOIs
StatePublished - Mar 2007

Keywords

  • Children
  • Cognitive rehabilitation
  • Executive function
  • Literature review
  • Neuroimaging
  • Pediatric neuropsychology
  • Sickle cell disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neuropsychology and Physiological Psychology
  • Developmental and Educational Psychology

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    Berkelhammer, L. D., Williamson, A. L., Sanford, S. D., Dirksen, C. L., Sharp, W. G., Margulies, A. S., & Prengler, R. A. (2007). Neurocognitive sequelae of pediatric sickle cell disease: A review of the literature. Child Neuropsychology, 13(2), 120-131. https://doi.org/10.1080/09297040600800956