Neurodegeneration in schizophrenia: Evidence from in vivo neuroimaging studies

John G. Csernansky*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


Although schizophrenia is primarily considered to be a neurodevelopmental disorder, there is a growing consensus that the disorder may also involve neurodegeneration. Recent research using non-invasive neuroimaging techniques, such as magnetic resonance imaging, suggests that some patients with schizophrenia show progressive losses of gray matter in the frontal and temporal lobes of the brain. The cellular mechanisms responsible for such gray matter losses are unknown, but have been hypothesized to involve abnormal increases in apoptosis.

Original languageEnglish (US)
Pages (from-to)135-143
Number of pages9
StatePublished - Feb 2 2007


  • Apoptosis
  • Glutamate
  • Neurodegeneration
  • Neuroimaging
  • Schizophrenia

ASJC Scopus subject areas

  • General Environmental Science
  • General Biochemistry, Genetics and Molecular Biology


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