Neurodevelopment of children with single suture craniosynostosis: A review

Kathleen A. Kapp-Simon*, Matthew L. Speltz, Michael L. Cunningham, Pravin K. Patel, Tadanori Tomita

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

141 Scopus citations

Abstract

Introduction: Rates of neurocognitive risk range from 35-50% of school-aged children with isolated single suture craniosynostosis (SSC). It has been hypothesized that early surgical intervention to release suture fusion reduces risk for increased intracranial pressure (ICP) and the corresponding risk to neurodevelopment. However, studies assessing children with SSC have been inconsistent in finding an association between neurocognitive development, age of surgery, and ICP. Review: SSC produces notable distortion of the cranial vault and underlying brain mass. Although a linear relationship between skull distortion, ICP, and neurocognitive deficits has generally been assumed, recent studies have postulated an interactive process between the skull and developing brain that results in neuroanatomical changes that are not limited to areas directly beneath the fused suture. The specific neuropsychological deficits identified in children with SSC including problems with attention and planning, processing speed, visual spatial skills, language, reading, and spelling may be related to the anatomic differences that persist after correction of suture fusion. Conclusions: Available literature on neurocognitive development of children with SSC is suggestive of mild but persistent neuropsychological deficits, which become more significant as cognitive demands increase at school age. Anatomical studies of children without SSC are beginning to identify particular groups of brain structures that if disrupted or malformed, may be associated with specific cognitive deficits. Controlled research investigating the relationship between persistent anatomical changes and neurocognitive functioning of school-aged children with SSC is needed.

Original languageEnglish (US)
Pages (from-to)269-281
Number of pages13
JournalChild's Nervous System
Volume23
Issue number3
DOIs
StatePublished - Mar 1 2007

Keywords

  • Cognition
  • Increased cranial pressure
  • Neurodevelopment
  • Neuroimaging
  • Single suture craniosynostosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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