TY - JOUR
T1 - Neurodevelopmental outcome of infantile spasms
T2 - A systematic review and meta-analysis
AU - Widjaja, Elysa
AU - Go, Cristina
AU - McCoy, Blathnaid
AU - Snead, OCarter C.
N1 - Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2015
Y1 - 2015
N2 - Background: The aims of this systematic review and meta-analysis were to assess (i) estimates of good neurodevelopmental outcome in infantile spasms (IS), (ii) if neurodevelopmental outcome has changed since the publication of the first guideline on medical treatment of IS in 2004 and (iii) effect of lead time to treatment (LTTT) Methods: The Medline, Embase, Cochrane, PsycINFO, Web of Science and Scopus databases, and reference lists of retrieved articles were searchedStudies inclusion criteria were: (i) >5 patients with IS, (ii) mean/median follow-up of >6 months, (iii) neurodevelopmental outcome, and (iv) randomized and observational studiesThe data extracted included proportion of good neurodevelopmental outcome, year of publication, cryptogenic or symptomatic IS and LTTT Results: Of the 1436 citations screened, 55 articles were included in final analysis, with a total of 2967 patientsThe pooled estimate for good neurodevelopmental outcome was 0.236 (95% CI: 0.193-0.286)There was no difference between the proportions of good neurodevelopmental outcome for the 21 studies published after 2004 [0.264 (95% CI: 0.197-0.344)] compared to the 34 studies published before 2004 [0.220 (95% CI: 0.168-0.283)] (Q value=0.862, p=0.353)The pooled estimate of good neurodevelopmental outcome for cryptogenic IS [0.543 (95% CI: 0.458-0.625)] was higher than symptomatic IS [0.125 (95% CI: 0.09-0.171)] (Q value=69.724, p<0.001)Risk ratio of LTTT <4weeks relative to >4weeks for good neurodevelopmental outcome of 8 studies was 1.519 (95% CI: 1.064-2.169) Conclusion: Neurodevelopmental outcome was overall poor in patients with IS and has not changed since the publication of first guideline on ISAlthough cryptogenic IS has better prognosis than symptomatic IS, the outcome for cryptogenic IS remained poorThere was heterogeneity in neurodevelopmental outcome ascertainment methods, highlighting the need for a more standardized and comprehensive assessment of cognitive, behavioural, emotional and functional outcomes.
AB - Background: The aims of this systematic review and meta-analysis were to assess (i) estimates of good neurodevelopmental outcome in infantile spasms (IS), (ii) if neurodevelopmental outcome has changed since the publication of the first guideline on medical treatment of IS in 2004 and (iii) effect of lead time to treatment (LTTT) Methods: The Medline, Embase, Cochrane, PsycINFO, Web of Science and Scopus databases, and reference lists of retrieved articles were searchedStudies inclusion criteria were: (i) >5 patients with IS, (ii) mean/median follow-up of >6 months, (iii) neurodevelopmental outcome, and (iv) randomized and observational studiesThe data extracted included proportion of good neurodevelopmental outcome, year of publication, cryptogenic or symptomatic IS and LTTT Results: Of the 1436 citations screened, 55 articles were included in final analysis, with a total of 2967 patientsThe pooled estimate for good neurodevelopmental outcome was 0.236 (95% CI: 0.193-0.286)There was no difference between the proportions of good neurodevelopmental outcome for the 21 studies published after 2004 [0.264 (95% CI: 0.197-0.344)] compared to the 34 studies published before 2004 [0.220 (95% CI: 0.168-0.283)] (Q value=0.862, p=0.353)The pooled estimate of good neurodevelopmental outcome for cryptogenic IS [0.543 (95% CI: 0.458-0.625)] was higher than symptomatic IS [0.125 (95% CI: 0.09-0.171)] (Q value=69.724, p<0.001)Risk ratio of LTTT <4weeks relative to >4weeks for good neurodevelopmental outcome of 8 studies was 1.519 (95% CI: 1.064-2.169) Conclusion: Neurodevelopmental outcome was overall poor in patients with IS and has not changed since the publication of first guideline on ISAlthough cryptogenic IS has better prognosis than symptomatic IS, the outcome for cryptogenic IS remained poorThere was heterogeneity in neurodevelopmental outcome ascertainment methods, highlighting the need for a more standardized and comprehensive assessment of cognitive, behavioural, emotional and functional outcomes.
KW - Infantile spasms
KW - Lead time to treatment
KW - Neurodevelopment
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U2 - 10.1016/j.eplepsyres.2014.11.012
DO - 10.1016/j.eplepsyres.2014.11.012
M3 - Article
C2 - 25524855
AN - SCOPUS:84922667637
SN - 0920-1211
VL - 109
SP - 155
EP - 162
JO - Epilepsy Research
JF - Epilepsy Research
IS - 1
ER -