Neuroengineering modeling of single neuron and neural interface

X. L. Hu, Y. T. Zhang*, J. Yao

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


The single neuron has attracted widespread attention as an elementary unit for understanding the electrophysiological mechanisms of nervous systems and for exploring the functions of biological neural networks. Over the past decades, much modeling work on neural interface has been presented in support of experimental findings in neural engineering. This article reviews the recent research results on modeling electrical activities of the single neuron, electrical synapse, neuromuscular junction, and neural interfaces at cochlea. Single neuron models vary form to illustrate how neurons fire and what the firing patterns mean. Focusing on these two questions, recent modeling work on single neurons is discussed. The modeling of neural receptors at inner and outer hair cells is examined to explain the transforming procedure from sounds to electrical signals. The low-pass characteristics of electrical synapse and neuromuscular junction are also discussed in an attempt to understand the mechanism of electrical transmission across the interfaces.

Original languageEnglish (US)
Pages (from-to)219-248
Number of pages30
JournalCritical Reviews in Biomedical Engineering
Issue number4-6
StatePublished - Dec 1 2002


  • Cochlea
  • Gap junction
  • Neural interface
  • Neuromuscular junction
  • Neuron models

ASJC Scopus subject areas

  • Biomedical Engineering

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