Neurogenetic basis for circadian regulation of metabolism by the hypothalamus

Jonathan Cedernaes, Nathan Waldeck, Joseph Bass

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Circadian rhythms are driven by a transcription–translation feedback loop that separates anabolic and catabolic processes across the Earth’s 24-h light–dark cycle. Central pacemaker neurons that perceive light entrain a distributed clock network and are closely juxtaposed with hypothalamic neurons involved in regulation of sleep/wake and fast/feeding states. Gaps remain in identifying how pacemaker and extrapacemaker neurons communicate with energy-sensing neurons and the distinct role of circuit interactions versus transcriptionally driven cell-autonomous clocks in the timing of organismal bioener-getics. In this review, we discuss the reciprocal relationship through which the central clock drives appetitive behavior and metabolic homeostasis and the pathways through which nutrient state and sleep/wake behavior affect central clock function.

Original languageEnglish (US)
Pages (from-to)1136-1158
Number of pages23
JournalGenes and Development
Issue number17-18
StatePublished - Sep 1 2019


  • Circadian
  • Diabetes
  • Hypothalamus
  • Obesity]

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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