Neurohormones, Neurodevelopment, and the Prodrome of Psychosis in Adolescence

Elaine F. Walker*, Amanda McMillan, Vijay Mittal

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


It has been suggested that the neural systems governing the response to stress, especially the hypothalamic-pituitary-adrenal (HPA) axis, may function to augment the expression of the core vulnerability to psychosis. This chapter reviews research findings that bear on adolescent vulnerability for psychosis and neurodevelopment of the HPA-hippocampal system, with an emphasis on implications for preventive intervention. The chapter presents preliminary data from recent research that suggests how psychopharmacologic interventions might alter HPA function, and thereby modify the transition to psychosis in at-risk adolescents.

Original languageEnglish (US)
Title of host publicationAdolescent Psychopathology and the Developing Brain
Subtitle of host publicationIntegrating Brain and Prevention Science
PublisherOxford University Press
ISBN (Electronic)9780199863914
ISBN (Print)0195306260, 9780195306255
StatePublished - Mar 22 2007


  • HPA function
  • Hypothalamic-pituitary-adrenal axis
  • Psychosis
  • Stress

ASJC Scopus subject areas

  • Neuroscience(all)


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