Neuroimaging in aphasia treatment research: Quantifying brain lesions after stroke

Jenny Crinion*, Audrey L. Holland, David A. Copland, Cynthia K. Thompson, Argye E. Hillis

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

New structural and functional neuroimaging methods continue to rapidly develop, offering promising tools for cognitive neuroscientists. In the last 20. years, advanced magnetic resonance imaging (MRI) techniques have provided invaluable insights into how language is represented and processed in the brain and how it can be disrupted by damage to, or dysfunction of, various parts of the brain. Current functional MRI (fMRI) approaches have also allowed researchers to purposefully investigate how individuals recover language after stroke. This paper presents recommendations for quantification of brain lesions derived from discussions among international researchers at the Neuroimaging in Aphasia Treatment Research Workshop held at Northwestern University (Evanston, Illinois, USA). Methods for detailing and characterizing the brain damage that can influence results of fMRI studies in chronic aphasic stroke patients are discussed. Moreover, we aimed to provide the reader with a set of general practical guidelines and references to facilitate choosing adequate structural imaging strategies that facilitate fMRI studies in aphasia treatment research.

Original languageEnglish (US)
Pages (from-to)208-214
Number of pages7
JournalNeuroimage
Volume73
DOIs
StatePublished - Jun 2013

Funding

This work was supported by the UK Medical Research Council Clinical Scientist Fellowship G0701888 (JC), the Australian Research Council Discovery grant ( DP0880556 ) and National Health and Medical Research Council Career Development Award (DC), and the National Institutes of Health, Institute on Deafness and other Communication Disorders : R01DCOI948‐17 and R01DC007213 (CT), and R01DC05375 (AH).

Keywords

  • Aphasia
  • Brain lesions
  • Language recovery
  • Stroke
  • Structural anatomy

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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