Neuroimaging in aphasia treatment research: Standards for establishing the effects of treatment

Swathi Kiran; Ana Ansaldo; Roelien Bastiaanse; Leora R. Cherney; David Howard; Yasmeen Faroqi-Shah; Marcus Meinzer; Cynthia K. Thompson

doi:10.1016/j.neuroimage.2012.10.011

Neuroimaging in aphasia treatment research: Standards for establishing the effects of treatment

Swathi Kiran^*, Ana Ansaldo, Roelien Bastiaanse, Leora R. Cherney, David Howard, Yasmeen Faroqi-Shah, Marcus Meinzer, Cynthia K. Thompson

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

The goal of this paper is to discuss experimental design options available for establishing the effects of treatment in studies that aim to examine the neural mechanisms associated with treatment-induced language recovery in aphasia, using functional magnetic resonance imaging (fMRI). We present both group and single-subject experimental or case-series design options for doing this and address advantages and disadvantages of each. We also discuss general components of and requirements for treatment research studies, including operational definitions of variables, criteria for defining behavioral change and treatment efficacy, and reliability of measurement. Important considerations that are unique to neuroimaging-based treatment research are addressed, pertaining to the relation between the selected treatment approach and anticipated changes in language processes/functions and how such changes are hypothesized to map onto the brain.

Original language	English (US)
Pages (from-to)	428-435
Number of pages	8
Journal	Neuroimage
Volume	76
DOIs	https://doi.org/10.1016/j.neuroimage.2012.10.011
State	Published - Aug 1 2013

Funding

This work was also supported in part by the National Institutes of Health, Institute on Deafness and Other Communication Disorders R01DC01948 and R01DC007213 (CT), K18DC011517-01 (SK); and R21DC9876 (LRC); the Bundesministerium für Bildung und Forschung, BMBF : 01EO0801 (MM) and The Heart and Stroke Foundation of Canada , and Fonds de la recherche en Santé du Québec (AIA).

Keywords

Aphasia
FMRI
Language recovery
Treatment efficacy

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

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10.1016/j.neuroimage.2012.10.011

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title = "Neuroimaging in aphasia treatment research: Standards for establishing the effects of treatment",

abstract = "The goal of this paper is to discuss experimental design options available for establishing the effects of treatment in studies that aim to examine the neural mechanisms associated with treatment-induced language recovery in aphasia, using functional magnetic resonance imaging (fMRI). We present both group and single-subject experimental or case-series design options for doing this and address advantages and disadvantages of each. We also discuss general components of and requirements for treatment research studies, including operational definitions of variables, criteria for defining behavioral change and treatment efficacy, and reliability of measurement. Important considerations that are unique to neuroimaging-based treatment research are addressed, pertaining to the relation between the selected treatment approach and anticipated changes in language processes/functions and how such changes are hypothesized to map onto the brain.",

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note = "Funding Information: This work was also supported in part by the National Institutes of Health, Institute on Deafness and Other Communication Disorders R01DC01948 and R01DC007213 (CT), K18DC011517-01 (SK); and R21DC9876 (LRC); the Bundesministerium f{\"u}r Bildung und Forschung, BMBF : 01EO0801 (MM) and The Heart and Stroke Foundation of Canada , and Fonds de la recherche en Sant{\'e} du Qu{\'e}bec (AIA).",

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AU - Howard, David

AU - Faroqi-Shah, Yasmeen

AU - Meinzer, Marcus

AU - Thompson, Cynthia K.

N1 - Funding Information: This work was also supported in part by the National Institutes of Health, Institute on Deafness and Other Communication Disorders R01DC01948 and R01DC007213 (CT), K18DC011517-01 (SK); and R21DC9876 (LRC); the Bundesministerium für Bildung und Forschung, BMBF : 01EO0801 (MM) and The Heart and Stroke Foundation of Canada , and Fonds de la recherche en Santé du Québec (AIA).

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AB - The goal of this paper is to discuss experimental design options available for establishing the effects of treatment in studies that aim to examine the neural mechanisms associated with treatment-induced language recovery in aphasia, using functional magnetic resonance imaging (fMRI). We present both group and single-subject experimental or case-series design options for doing this and address advantages and disadvantages of each. We also discuss general components of and requirements for treatment research studies, including operational definitions of variables, criteria for defining behavioral change and treatment efficacy, and reliability of measurement. Important considerations that are unique to neuroimaging-based treatment research are addressed, pertaining to the relation between the selected treatment approach and anticipated changes in language processes/functions and how such changes are hypothesized to map onto the brain.

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KW - Language recovery

KW - Treatment efficacy

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Neuroimaging in aphasia treatment research: Standards for establishing the effects of treatment

Abstract

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Keywords

ASJC Scopus subject areas

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