Neuroimaging of pain: Possibilities of objective measurements of analgesic actions in human subjects

David Borsook, Lino Becerra, Alison Comite, Gil Gonzalez, Hans C Breiter

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


A major pursuit in neurobiology is to understand the mechanism by which the organism reacts to sensory information. Central nervous system (CNS) regions, from peripheral nerve to cortex, activated by painful stimuli can be defined using electrophysiological recordings or markers of activity, such as the immediate early gene fos (Hunt et al., 1987). Animal studies are limited because it is difficult to quantify affective responses to pain, and they may not completely model the human experience. Recent advances in neuroimaging techniques offer tools to understand integrative neuronal processing in acute and chronic pain. Plastic changes producing alterations in sensory processing in patients with neuropathic pain (Flor et aI., 1994; Borsook et aI., 1998), the potential objective measurement of the chronic pain state (Iadarola et aI., 1995), and the objective response to analgesic actions are potential areas of investigation.

Original languageEnglish (US)
Title of host publicationPain
Subtitle of host publicationCurrent Understanding, Emerging Therapies, and Novel Approaches to Drug Discovery
PublisherCRC Press
Number of pages11
ISBN (Electronic)9780203911259
ISBN (Print)0824788656, 9780824788650
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Health Professions(all)
  • Medicine(all)


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