TY - JOUR
T1 - Neurokinin-1 receptors are decreased in major depressive disorder
AU - Stockmeier, Craig A.
AU - Shi, Xiaochun
AU - Konick, Lisa
AU - Overholser, James C.
AU - Jurjus, George
AU - Meltzer, Herbert Y.
AU - Friedman, Lee
AU - Blier, Pierre
AU - Rajkowska, Grazyna
PY - 2002/7/2
Y1 - 2002/7/2
N2 - Treatment with an antagonist at the neurokinin-I (NK-1) receptor may alleviate depression, however the brain region(s) in which the NK-1 receptor antagonist exerts its therapeutic effect is unknown. [1251]BH-Substance P was used to measure NK-1 receptors postmortem in cytoarchitectonically defined areas of rostral orbitofrontal cortex (Brodmann's area 47) of subjects with major depressive disorder (n = 12, six females) and psychiatrically normal subjects (n = 11, five females). Six subjects with depression died by suicide. Subjects with depression showed decreased binding to NK-1 receptors across all cortical layers (p = 0.024). The pathophysiology of depression, and the reported therapeutic benefit of NK-1 receptor antagonists, may thus involve NK-1 receptors in prefrontal cortex.
AB - Treatment with an antagonist at the neurokinin-I (NK-1) receptor may alleviate depression, however the brain region(s) in which the NK-1 receptor antagonist exerts its therapeutic effect is unknown. [1251]BH-Substance P was used to measure NK-1 receptors postmortem in cytoarchitectonically defined areas of rostral orbitofrontal cortex (Brodmann's area 47) of subjects with major depressive disorder (n = 12, six females) and psychiatrically normal subjects (n = 11, five females). Six subjects with depression died by suicide. Subjects with depression showed decreased binding to NK-1 receptors across all cortical layers (p = 0.024). The pathophysiology of depression, and the reported therapeutic benefit of NK-1 receptor antagonists, may thus involve NK-1 receptors in prefrontal cortex.
KW - Depression
KW - Neurokinin-1 receptor
KW - Orbitofrontal cortex
KW - Postmortem
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U2 - 10.1097/00001756-200207020-00031
DO - 10.1097/00001756-200207020-00031
M3 - Article
C2 - 12151774
AN - SCOPUS:0037007968
SN - 0959-4965
VL - 13
SP - 1223
EP - 1227
JO - Neuroreport
JF - Neuroreport
IS - 9
ER -