Neurokinin-1 receptors are decreased in major depressive disorder

Craig A. Stockmeier; Xiaochun Shi; Lisa Konick; James C. Overholser; George Jurjus; Herbert Y. Meltzer; Lee Friedman; Pierre Blier; Grazyna Rajkowska

doi:10.1097/00001756-200207020-00031

Neurokinin-1 receptors are decreased in major depressive disorder

Craig A. Stockmeier^*, Xiaochun Shi, Lisa Konick, James C. Overholser, George Jurjus, Herbert Y. Meltzer, Lee Friedman, Pierre Blier, Grazyna Rajkowska

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Treatment with an antagonist at the neurokinin-I (NK-1) receptor may alleviate depression, however the brain region(s) in which the NK-1 receptor antagonist exerts its therapeutic effect is unknown. [¹²⁵1]BH-Substance P was used to measure NK-1 receptors postmortem in cytoarchitectonically defined areas of rostral orbitofrontal cortex (Brodmann's area 47) of subjects with major depressive disorder (n = 12, six females) and psychiatrically normal subjects (n = 11, five females). Six subjects with depression died by suicide. Subjects with depression showed decreased binding to NK-1 receptors across all cortical layers (p = 0.024). The pathophysiology of depression, and the reported therapeutic benefit of NK-1 receptor antagonists, may thus involve NK-1 receptors in prefrontal cortex.

Original language	English (US)
Pages (from-to)	1223-1227
Number of pages	5
Journal	Neuroreport
Volume	13
Issue number	9
DOIs	https://doi.org/10.1097/00001756-200207020-00031
State	Published - Jul 2 2002

Keywords

Depression
Neurokinin-1 receptor
Orbitofrontal cortex
Postmortem

ASJC Scopus subject areas

General Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/00001756-200207020-00031

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title = "Neurokinin-1 receptors are decreased in major depressive disorder",

abstract = "Treatment with an antagonist at the neurokinin-I (NK-1) receptor may alleviate depression, however the brain region(s) in which the NK-1 receptor antagonist exerts its therapeutic effect is unknown. [1251]BH-Substance P was used to measure NK-1 receptors postmortem in cytoarchitectonically defined areas of rostral orbitofrontal cortex (Brodmann's area 47) of subjects with major depressive disorder (n = 12, six females) and psychiatrically normal subjects (n = 11, five females). Six subjects with depression died by suicide. Subjects with depression showed decreased binding to NK-1 receptors across all cortical layers (p = 0.024). The pathophysiology of depression, and the reported therapeutic benefit of NK-1 receptor antagonists, may thus involve NK-1 receptors in prefrontal cortex.",

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AU - Stockmeier, Craig A.

AU - Shi, Xiaochun

AU - Konick, Lisa

AU - Overholser, James C.

AU - Jurjus, George

AU - Meltzer, Herbert Y.

AU - Friedman, Lee

AU - Blier, Pierre

AU - Rajkowska, Grazyna

PY - 2002/7/2

Y1 - 2002/7/2

N2 - Treatment with an antagonist at the neurokinin-I (NK-1) receptor may alleviate depression, however the brain region(s) in which the NK-1 receptor antagonist exerts its therapeutic effect is unknown. [1251]BH-Substance P was used to measure NK-1 receptors postmortem in cytoarchitectonically defined areas of rostral orbitofrontal cortex (Brodmann's area 47) of subjects with major depressive disorder (n = 12, six females) and psychiatrically normal subjects (n = 11, five females). Six subjects with depression died by suicide. Subjects with depression showed decreased binding to NK-1 receptors across all cortical layers (p = 0.024). The pathophysiology of depression, and the reported therapeutic benefit of NK-1 receptor antagonists, may thus involve NK-1 receptors in prefrontal cortex.

AB - Treatment with an antagonist at the neurokinin-I (NK-1) receptor may alleviate depression, however the brain region(s) in which the NK-1 receptor antagonist exerts its therapeutic effect is unknown. [1251]BH-Substance P was used to measure NK-1 receptors postmortem in cytoarchitectonically defined areas of rostral orbitofrontal cortex (Brodmann's area 47) of subjects with major depressive disorder (n = 12, six females) and psychiatrically normal subjects (n = 11, five females). Six subjects with depression died by suicide. Subjects with depression showed decreased binding to NK-1 receptors across all cortical layers (p = 0.024). The pathophysiology of depression, and the reported therapeutic benefit of NK-1 receptor antagonists, may thus involve NK-1 receptors in prefrontal cortex.

KW - Depression

KW - Neurokinin-1 receptor

KW - Orbitofrontal cortex

KW - Postmortem

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Neurokinin-1 receptors are decreased in major depressive disorder

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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