Neuroleptic influences on a lateralized behavioral bias in unoperated rats

George Taylor*, Mark Bardgett, John Csernansky, Terry Early, John Haller, Jeff Scherrer, Sharon Womack

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Rationale: Abnormalities of the ascending dopaminergic system have been associated with hemineglect, and evidence suggests that neuroleptic treatments normalize the right hemispatial attentional impairment that is sometimes observed in acutely psychotic schizophrenic patients. Objective: A research program was initiated to develop an animal model of hemineglect- drug interactions. Methods: Female rats were tested repeatedly on removing a 'nuisance stimulus' - strips of surgical tape applied loosely to the forelimbs. Subjects were assigned to groups dependent upon showing a behavioral orientation preference (BOP) during pre-drug baseline tests. Animals representing left-BOP, right-BOP and no preference continued to be tested during chronic exposure either to a dopamine antagonist (0.05 mg haloperidol/kg) or agonist (1.0 mg d-amphetamine/kg) or vehicle only. Results: Three weeks of haloperidol treatments to rats only with an initial right BOP gradually eliminated the response bias, as revealed by declines in choosing the right forepaw and the latencies between attending to the two forepaws. Conclusion: The results recommend right BOP female rats as a simple, non-invasive behavioral animal model for evaluating and comparing neuroleptic medications.

Original languageEnglish (US)
Pages (from-to)30-37
Number of pages8
JournalPsychopharmacology
Volume144
Issue number1
DOIs
StatePublished - 1999

Keywords

  • Animal model
  • Antipsychotic drug
  • Dopamine
  • Hemineglect
  • Laterality
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmacology

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