Neurologic complications of patients with small cell prostate carcinoma. Report of two cases

Michael T. Lyster, Merrill S. Kies, Timothy M. Kuzel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background. Primary small cell carcinoma arising in organs other than the lung were thought to be relatively rare. However, with the increasing technical sophistication of pathology departments, tumors with foci of small cell neuroendocrine components are being identified more frequently. The pattern of disease involvement and optimal treatment have yet to be defined. Methods. Two cases of primary small cell carcinoma of the prostate are described in which patients previously had unreported degrees of central nervous system disease. Results. Approximately 75 cases of small cell carcinoma of the prostate have been reported. Neurologic complications have been reported infrequently, although a variety of neurologic paraneoplastic sequelae have been noted. However, carcinomatous meningitis or develapment of intraductal tumors without concomitant vertebral bone disease has never been reported. These tumors respond poorly to hormonal therapy alone, and recent reports suggest optimal therapeutic strategies may involve combination hormone and chemotherapy. Conclusion. Small cell carcinoma of the prostate must be recognized when it arises de novo or with components of adenocarcinoma because the prognoses and response to treatment differs from the more common adenocarcinomas of the prostate.

Original languageEnglish (US)
Pages (from-to)3159-3163
Number of pages5
Issue number12
StatePublished - Dec 15 1994


  • chemotherapy
  • extrapulmonary small cell cancer
  • neuroendocrine tumors
  • prostate cancer
  • prostatic neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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