TY - JOUR
T1 - Neurological complications of cardiac surgery
AU - Gottesman, Rebecca F.
AU - McKhann, Guy M.
AU - Hogue, Charles W.
N1 - Funding Information:
DLM is a consultant for Cephalogics Corporation, LLC. CG receives research funding from Edge Therapeutics, AstraZeneca, Ornim, and Zoll Corporation. The other authors declare that they have no competing interests.
Funding Information:
This work was funded by the Duke University Department of Anesthesiology and was supported in part by grants HL096978, HL108280, and HL109971 (to JPM) from the National Institutes of Health (Washington, DC, USA). We thank Kathy Gage (Department of Anesthesiology Duke University, NC, USA) for editorial assistance.
PY - 2008/11
Y1 - 2008/11
N2 - Neurological injury resulting from cardiac surgery has a range of manifestations from focal neurological deficit to encephalopathy or coma. As the safety of drug-eluting stents comes into question, more patients will likely undergo coronary artery bypass graft surgery. These projections, along with the growing proportions of elderly patients and those with comorbidities, portend the potential for rising rates of perioperative neurological complications. The risk for neurological injury may be determined by the type of procedure, by patient-specific characteristics, and by the extent of cerebral embolization and hypoperfusion during and after surgery. Changes in surgical techniques, including the use of off-pump surgery, have not decreased rates of brain injury from cardiac surgery. When appropriate, modern neuroimaging techniques should be used in postoperative patients to confirm diagnosis, to provide information on potential etiology, to direct appropriate therapy, and to help in prognostication. Management of postoperative medications and early use of rehabilitation services is a recommended strategy to optimize the recovery for individuals with neurological injury after cardiac surgery.
AB - Neurological injury resulting from cardiac surgery has a range of manifestations from focal neurological deficit to encephalopathy or coma. As the safety of drug-eluting stents comes into question, more patients will likely undergo coronary artery bypass graft surgery. These projections, along with the growing proportions of elderly patients and those with comorbidities, portend the potential for rising rates of perioperative neurological complications. The risk for neurological injury may be determined by the type of procedure, by patient-specific characteristics, and by the extent of cerebral embolization and hypoperfusion during and after surgery. Changes in surgical techniques, including the use of off-pump surgery, have not decreased rates of brain injury from cardiac surgery. When appropriate, modern neuroimaging techniques should be used in postoperative patients to confirm diagnosis, to provide information on potential etiology, to direct appropriate therapy, and to help in prognostication. Management of postoperative medications and early use of rehabilitation services is a recommended strategy to optimize the recovery for individuals with neurological injury after cardiac surgery.
KW - Cardiopulmonary bypass
KW - Postoperative complications
KW - Stroke
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U2 - 10.1055/s-0028-1105973
DO - 10.1055/s-0028-1105973
M3 - Review article
C2 - 19115176
AN - SCOPUS:58849160804
SN - 0271-8235
VL - 28
SP - 703
EP - 715
JO - Seminars in Neurology
JF - Seminars in Neurology
IS - 5
ER -