Neurological disease: UPS stops delivering!

Richard J. Miller*, Scott M. Wilson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


The ubiquitin-proteasome system (UPS) plays a vital role in directing molecules to the 26S proteasome for degradation as well as other locales in the cell. Disrupting UPS function can lead to the aggregation of mutant or misfolded proteins, which disrupts normal cellular activity in diverse ways. Here we discuss how UPS dysfunction might contribute to a variety of neurological problems.

Original languageEnglish (US)
Pages (from-to)18-23
Number of pages6
JournalTrends in Pharmacological Sciences
Issue number1
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology


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