Neurological disease: UPS stops delivering!

Richard J. Miller; Scott M. Wilson

doi:10.1016/S0165-6147(02)00011-1

Neurological disease: UPS stops delivering!

Richard J. Miller^*, Scott M. Wilson

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The ubiquitin-proteasome system (UPS) plays a vital role in directing molecules to the 26S proteasome for degradation as well as other locales in the cell. Disrupting UPS function can lead to the aggregation of mutant or misfolded proteins, which disrupts normal cellular activity in diverse ways. Here we discuss how UPS dysfunction might contribute to a variety of neurological problems.

Original language	English (US)
Pages (from-to)	18-23
Number of pages	6
Journal	Trends in Pharmacological Sciences
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/S0165-6147(02)00011-1
State	Published - Jan 1 2003

ASJC Scopus subject areas

Toxicology
Pharmacology

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10.1016/S0165-6147(02)00011-1

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abstract = "The ubiquitin-proteasome system (UPS) plays a vital role in directing molecules to the 26S proteasome for degradation as well as other locales in the cell. Disrupting UPS function can lead to the aggregation of mutant or misfolded proteins, which disrupts normal cellular activity in diverse ways. Here we discuss how UPS dysfunction might contribute to a variety of neurological problems.",

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Neurological disease: UPS stops delivering!

Abstract

ASJC Scopus subject areas

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