Neurological manifestations of acquired immunodeficiency syndrome in children

M. Mintz, L. G. Epstein, M. R. Koenigsberger

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The incidence, transmission, diagnosis, classification and systemic aspects of human immunodeficiency virus-type 1 (HIV-1) infection in the pediatric population are discussed. We have reviewed the clinical, neuropathologic, radiologic, laboratory and pathogenic mechanisms of the neurologic manifestations HIV-1 infection. In our cohort of 159 children with HIV-1 infection, we have retrospectively found an overall incidence of progressive encephalopathy of 55% (87/159), or 74% (87/118) in children with the acquired immunodeficiency syndrome (AIDS). Impaired brain growth (93%), progressive motor dysfunction (90%), and loss or plateau of developmental milestones (76%) were the predominant findings in children with progressive encephalopathy (N = 87). The diagnosis of progressive encephalopathy bears a grim prognosis, with a retrospective mortality of 60%, compared to 47% with a diagnosis of AIDS alone, in our cohort. Various treatment regimens are discussed.

Original languageEnglish (US)
Pages (from-to)161-171
Number of pages11
JournalInternational Pediatrics
Issue number2
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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