TY - JOUR
T1 - Neurological manifestations of acquired immunodeficiency syndrome in children
AU - Mintz, M.
AU - Epstein, L. G.
AU - Koenigsberger, M. R.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - The incidence, transmission, diagnosis, classification and systemic aspects of human immunodeficiency virus-type 1 (HIV-1) infection in the pediatric population are discussed. We have reviewed the clinical, neuropathologic, radiologic, laboratory and pathogenic mechanisms of the neurologic manifestations HIV-1 infection. In our cohort of 159 children with HIV-1 infection, we have retrospectively found an overall incidence of progressive encephalopathy of 55% (87/159), or 74% (87/118) in children with the acquired immunodeficiency syndrome (AIDS). Impaired brain growth (93%), progressive motor dysfunction (90%), and loss or plateau of developmental milestones (76%) were the predominant findings in children with progressive encephalopathy (N = 87). The diagnosis of progressive encephalopathy bears a grim prognosis, with a retrospective mortality of 60%, compared to 47% with a diagnosis of AIDS alone, in our cohort. Various treatment regimens are discussed.
AB - The incidence, transmission, diagnosis, classification and systemic aspects of human immunodeficiency virus-type 1 (HIV-1) infection in the pediatric population are discussed. We have reviewed the clinical, neuropathologic, radiologic, laboratory and pathogenic mechanisms of the neurologic manifestations HIV-1 infection. In our cohort of 159 children with HIV-1 infection, we have retrospectively found an overall incidence of progressive encephalopathy of 55% (87/159), or 74% (87/118) in children with the acquired immunodeficiency syndrome (AIDS). Impaired brain growth (93%), progressive motor dysfunction (90%), and loss or plateau of developmental milestones (76%) were the predominant findings in children with progressive encephalopathy (N = 87). The diagnosis of progressive encephalopathy bears a grim prognosis, with a retrospective mortality of 60%, compared to 47% with a diagnosis of AIDS alone, in our cohort. Various treatment regimens are discussed.
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M3 - Article
AN - SCOPUS:0024409577
VL - 4
SP - 161
EP - 171
JO - International Pediatrics
JF - International Pediatrics
SN - 0885-6265
IS - 2
ER -