Neuromodulatory control of striatal plasticity and behavior

Talia N. Lerner, Anatol C. Kreitzer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

Excitatory synapses onto projection neurons in the striatum, the input nucleus of the basal ganglia, play a key role in regulating basal ganglia circuit function and are a major site of long-term synaptic plasticity. Here, we review the mechanisms and regulation of both long-term potentiation and long-term depression at these synapses. In particular, we highlight the role that neuromodulators play in determining the strength and direction of plasticity, which ultimately shapes the balance of activity in basal ganglia circuits and regulates motor behavior.

Original languageEnglish (US)
Pages (from-to)322-327
Number of pages6
JournalCurrent Opinion in Neurobiology
Volume21
Issue number2
DOIs
StatePublished - Apr 1 2011

ASJC Scopus subject areas

  • Neuroscience(all)

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