TY - JOUR
T1 - Neuromuscular hamartoma of the sciatic nerve
T2 - Case report and review of the literature
AU - Lam, Sandi
AU - Grandhi, Ramesh
AU - Wong, Ricky
AU - Hamilton, Ronald
AU - Greene, Stephanie
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Background: Neuromuscular hamartomas are rare benign tumors with mature skeletal elements mixed with mature neural elements. They present typically as solitary lesions in childhood and have been reported to be associated with cranial nerves or large peripheral nerves such as the brachial plexus, median nerve, and sciatic nerve. To date, eight cases of sciatic nerve neuromuscular hamartomas have been reported. We present a case along with an outline for the natural history of the disease with a review of the literature of the reported cases dating back to 1895. Case Description: An 11-year-old boy presented with progressive right lower extremity pain and atrophy. Magnetic resonance imaging revealed a large right sciatic nerve mass, and electromyography demonstrated evidence of ongoing denervation and reinnervation. Initial computed tomography-guided biopsy was unrevealing and subsequent open biopsy was consistent with neuromuscular choristoma. Conclusion: Neuromuscular choristomas represent a rare disease. Symptoms of foot deformity, leg size discrepancy, and pain merit a complete work-up including spinal and peripheral nerve etiologies.
AB - Background: Neuromuscular hamartomas are rare benign tumors with mature skeletal elements mixed with mature neural elements. They present typically as solitary lesions in childhood and have been reported to be associated with cranial nerves or large peripheral nerves such as the brachial plexus, median nerve, and sciatic nerve. To date, eight cases of sciatic nerve neuromuscular hamartomas have been reported. We present a case along with an outline for the natural history of the disease with a review of the literature of the reported cases dating back to 1895. Case Description: An 11-year-old boy presented with progressive right lower extremity pain and atrophy. Magnetic resonance imaging revealed a large right sciatic nerve mass, and electromyography demonstrated evidence of ongoing denervation and reinnervation. Initial computed tomography-guided biopsy was unrevealing and subsequent open biopsy was consistent with neuromuscular choristoma. Conclusion: Neuromuscular choristomas represent a rare disease. Symptoms of foot deformity, leg size discrepancy, and pain merit a complete work-up including spinal and peripheral nerve etiologies.
KW - Neuromuscular choristoma
KW - neuromuscular hamartoma
KW - peripheral nerve tumor
KW - sciatic nerve tumor
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U2 - 10.4103/2152-7806.106266
DO - 10.4103/2152-7806.106266
M3 - Article
C2 - 23493803
AN - SCOPUS:84875200664
SN - 2152-7806
VL - 4
JO - Surgical Neurology International
JF - Surgical Neurology International
IS - 1
M1 - 106266
ER -