Neuron activity in rat hippocampus and motor cortex during discrimination reversal

John F. Disterhoft; Menahem Segal

doi:10.1016/0361-9230(78)90003-5

Neuron activity in rat hippocampus and motor cortex during discrimination reversal

John F. Disterhoft^*, Menahem Segal

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

DISTERHOFT, J. F. AND M. SEGAL. Neuron activity in rat hippocampus and motor cortex during discrimination reversal. BRAIN RES. BULL. 3(6) 583-588, 1978.-Chronic unit activity and gross movement were recorded from rats during two discrimination reversals in a classical appetitive conditioning situation. The anticipatory movement decreased in response to the former CS⁺ tone and increased to the previous CS^- tone after each reversal. Hippocampus and motor cortex were differently related to these two kinds of behavioral change. Response rates of hippocampal neurons were more closely related to the increased movement response to the former CS^- which now signaled food. Motor cortex neuron responses were more closely correlated with the decrease in movement responses to the former CS⁺ which became neutral after the reversal. It appeared that hippocampal neurons could have been involved in one cognitive aspect of the situation, motor cortex neurons in another. The data were related to current functional concepts of these brain regions.

Original language	English (US)
Pages (from-to)	583-588
Number of pages	6
Journal	Brain Research Bulletin
Volume	3
Issue number	6
DOIs	https://doi.org/10.1016/0361-9230(78)90003-5
State	Published - 1978

Keywords

Cortex
Discrimination reversal
Hippocampus
Units

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0361-9230(78)90003-5

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@article{aa8ce424f2324c05a10e3d5e0b07cca0,

title = "Neuron activity in rat hippocampus and motor cortex during discrimination reversal",

abstract = "DISTERHOFT, J. F. AND M. SEGAL. Neuron activity in rat hippocampus and motor cortex during discrimination reversal. BRAIN RES. BULL. 3(6) 583-588, 1978.-Chronic unit activity and gross movement were recorded from rats during two discrimination reversals in a classical appetitive conditioning situation. The anticipatory movement decreased in response to the former CS+ tone and increased to the previous CS- tone after each reversal. Hippocampus and motor cortex were differently related to these two kinds of behavioral change. Response rates of hippocampal neurons were more closely related to the increased movement response to the former CS- which now signaled food. Motor cortex neuron responses were more closely correlated with the decrease in movement responses to the former CS+ which became neutral after the reversal. It appeared that hippocampal neurons could have been involved in one cognitive aspect of the situation, motor cortex neurons in another. The data were related to current functional concepts of these brain regions.",

keywords = "Cortex, Discrimination reversal, Hippocampus, Units",

author = "Disterhoft, {John F.} and Menahem Segal",

note = "Funding Information: {\textquoteleft}This work was supported by NIH Grant MH-16978 and GM-02031 to J. Olds and NS-MH-12317 to J. Disterhoft. Anthony Fellowship. The support and advice of the late Professor James Olds was very much appreciated. {\textquoteleft}Present address: Department of Anatomy, Northwestern University Medical School, Chicago, IL 60611. “Present address: Department of Isotope Research, The Weizmann Institute of Science, Rehovot, Israel.",

year = "1978",

doi = "10.1016/0361-9230(78)90003-5",

language = "English (US)",

volume = "3",

pages = "583--588",

journal = "Brain Research Bulletin",

issn = "0361-9230",

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T1 - Neuron activity in rat hippocampus and motor cortex during discrimination reversal

AU - Disterhoft, John F.

AU - Segal, Menahem

N1 - Funding Information: ‘This work was supported by NIH Grant MH-16978 and GM-02031 to J. Olds and NS-MH-12317 to J. Disterhoft. Anthony Fellowship. The support and advice of the late Professor James Olds was very much appreciated. ‘Present address: Department of Anatomy, Northwestern University Medical School, Chicago, IL 60611. “Present address: Department of Isotope Research, The Weizmann Institute of Science, Rehovot, Israel.

PY - 1978

Y1 - 1978

N2 - DISTERHOFT, J. F. AND M. SEGAL. Neuron activity in rat hippocampus and motor cortex during discrimination reversal. BRAIN RES. BULL. 3(6) 583-588, 1978.-Chronic unit activity and gross movement were recorded from rats during two discrimination reversals in a classical appetitive conditioning situation. The anticipatory movement decreased in response to the former CS+ tone and increased to the previous CS- tone after each reversal. Hippocampus and motor cortex were differently related to these two kinds of behavioral change. Response rates of hippocampal neurons were more closely related to the increased movement response to the former CS- which now signaled food. Motor cortex neuron responses were more closely correlated with the decrease in movement responses to the former CS+ which became neutral after the reversal. It appeared that hippocampal neurons could have been involved in one cognitive aspect of the situation, motor cortex neurons in another. The data were related to current functional concepts of these brain regions.

AB - DISTERHOFT, J. F. AND M. SEGAL. Neuron activity in rat hippocampus and motor cortex during discrimination reversal. BRAIN RES. BULL. 3(6) 583-588, 1978.-Chronic unit activity and gross movement were recorded from rats during two discrimination reversals in a classical appetitive conditioning situation. The anticipatory movement decreased in response to the former CS+ tone and increased to the previous CS- tone after each reversal. Hippocampus and motor cortex were differently related to these two kinds of behavioral change. Response rates of hippocampal neurons were more closely related to the increased movement response to the former CS- which now signaled food. Motor cortex neuron responses were more closely correlated with the decrease in movement responses to the former CS+ which became neutral after the reversal. It appeared that hippocampal neurons could have been involved in one cognitive aspect of the situation, motor cortex neurons in another. The data were related to current functional concepts of these brain regions.

KW - Cortex

KW - Discrimination reversal

KW - Hippocampus

KW - Units

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ER -

Neuron activity in rat hippocampus and motor cortex during discrimination reversal

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